Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CFTR | P13569 | 7/20 | 0.39 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.38 |
| ▸ | RET | P07949 | 1/20 | 0.38 |
| ▸ | SRC | P12931 | 6/20 | 0.37 |
| ▸ | LCK | P06239 | 2/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.35 |
| ▸ | TEK | Q02763 | 1/20 | 0.35 |
| ▸ | ABL1 | P00519 | 1/20 | 0.35 |
| ▸ | EGFR | P00533 | 1/20 | 0.35 |
| ▸ | ABL2 | P42684 | 1/20 | 0.35 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.35 |
| ▸ | IGF1R | P08069 | 1/20 | 0.34 |
| ▸ | EIF2AK3 | Q9NZJ5 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20173317 | 0.81 | ATR (0.44) | CFTRNOTUMRETSRCLCK | |
| SCHEMBL21187310 | 0.81 | CFTR (0.46) | CFTRNOTUMRETSRCLCK | |
| SCHEMBL20173316 | 0.80 | PIK3CD (0.45) | CFTRNOTUMSRCLCKRIPK2 | |
| SCHEMBL23481428 | 0.80 | EIF2AK3 (0.41) | CFTRNOTUMRETSRCLCK | |
| SCHEMBL20162759 | 0.79 | DOT1L (0.42) | CFTRNOTUMRETSRCLCK | |
| SCHEMBL20173321 | 0.79 | SRC (0.52) | NOTUMSRCLCKRIPK2TEK | |
| SCHEMBL20181897 | 0.78 | SRC (0.42) | CFTRNOTUMSRCLCKRIPK2 | |
| SCHEMBL30037245 | 0.78 | CFTR (0.41) | CFTRNOTUMRETSRCLCK | |
| SCHEMBL20162676 | 0.78 | CFTR (0.41) | CFTRNOTUMRETSRCLCK | |
| SCHEMBL21187270 | 0.77 | EIF2AK3 (0.44) | CFTRRETSRCLCKTEK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4424311-A2 | PYRROLOPYRIMIDINES AS CFTR POTENTIATORS | Cystic Fibrosis Foundation (US) | 2024-09-04 | — | — | EP | disclosed |
| EP-3541390-B1 | PYRROLOPYRIMIDINES AS CFTR POTENTIATORS | CYSTIC FIBROSIS FOUND (US) | 2024-05-01 | — | — | EP | disclosed |