SCHEMBL27208784

SCHEMBL27208784

CC(C)(C)OC(=O)NC(Cc1ncc(Br)cc1F)C(=O)O

nearest known ligand 0.48

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
PTPN1 P18031 2/20 0.48
ACE P12821 1/20 0.47
AAK1 Q2M2I8 5/20 0.46
ITGB3 P05106 1/20 0.44
ITGA2B P08514 1/20 0.44
CTSS P25774 7/20 0.43
CTSK P43235 6/20 0.43
CTSB P07858 1/20 0.43
IDO1 P14902 1/20 0.42
ITGA4 P13612 1/20 0.41
ITGB7 P26010 1/20 0.41
PPARA Q07869 2/20 0.40
PPARG P37231 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27207972 1.00 PTPN1 (0.48) PTPN1ACEAAK1ITGB3ITGA2B
SCHEMBL30987832 0.90 AAK1 (0.45) PTPN1ACEAAK1CTSSCTSK
SCHEMBL16064072 0.80 CTSS (0.53) PTPN1ACEAAK1ITGB3ITGA2B
SCHEMBL16447830 0.80 CTSS (0.53) PTPN1ACEAAK1ITGB3ITGA2B
SCHEMBL2943289 0.79 AAK1 (0.45) AAK1IDO1
SCHEMBL27230489 0.79 PTPN1 (0.42) PTPN1ACEAAK1ITGB3ITGA2B
SCHEMBL27207979 0.79 PTPN1 (0.42) PTPN1ACEAAK1ITGB3ITGA2B
SCHEMBL2002586 0.79 CTSS (0.50) PTPN1ACEAAK1ITGB3ITGA2B
SCHEMBL4066188 0.79 CTSS (0.50) PTPN1ACEAAK1ITGB3ITGA2B
SCHEMBL22128304 0.79 ACE (0.54) PTPN1ACEITGB3ITGA2BCTSS

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4361159-A1 BORONO-PHENYLALANINE DERIVATIVE Stella Pharma Corporation (JP) 2024-05-01 EP disclosed