Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Arginine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPY4R | P50391 | 4/20 | 0.31 |
| ▸ | NPY1R | P25929 | 3/20 | 0.31 |
| ▸ | NPY2R | P49146 | 2/20 | 0.31 |
| ▸ | NPY5R | Q15761 | 2/20 | 0.31 |
| ▸ | FNTA | P49354 | 4/20 | 0.31 |
| ▸ | FNTB | P49356 | 4/20 | 0.31 |
| ▸ | PGGT1B | P53609 | 4/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Arginine SCHEMBL2720905 | 0.94 | NPY1R (0.31) | NPY4RNPY1R | |
| Arginine SCHEMBL5502739 | 0.93 | APLNR (0.31) | NPY4RNPY1RNPY2RNPY5RFNTA | |
| Arginine SCHEMBL23242195 | 0.90 | OTC (0.34) | NPY4RNPY1RNPY2RNPY5RFNTA | |
| Arginine SCHEMBL23242198 | 0.90 | OTC (0.34) | NPY4RNPY1RNPY2RNPY5RFNTA | |
| Arginine SCHEMBL23242474 | 0.90 | OTC (0.34) | NPY4RNPY1RNPY2RNPY5RFNTA | |
| Arginine SCHEMBL15676652 | 0.90 | OTC (0.34) | NPY4RNPY1RNPY2RNPY5RFNTA | |
| Arginine SCHEMBL4587139 | 0.89 | NPY4R (0.32) | NPY4RNPY1RNPY2RNPY5RFNTA | |
| Arginine SCHEMBL16762310 | 0.88 | GSR (0.34) | NPY4RNPY1RNPY2RNPY5R | |
| Arginine SCHEMBL5507078 | 0.87 | OTC (0.32) | NPY4RNPY1RNPY2RNPY5RFNTA | |
| Arginine SCHEMBL5507081 | 0.87 | OTC (0.32) | NPY4RNPY1RNPY2RNPY5RFNTA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021195716-A1 | ANTIBIOTIC CONJUGATES | MONASH UNIVERSITY (AU) | 2021-10-07 | — | — | WO | disclosed |
| EP-3126376-A1 | POLYMYXIN DERIVATIVES AS ANTIMICROBIAL COMPOUNDS | Monash University (AU) | 2017-02-08 | — | — | EP | disclosed |
| WO-2015149131-A1 | POLYMYXIN DERIVATIVES AS ANTIMICROBIAL COMPOUNDS | MONASH UNIVERSITY (AU) | 2015-10-08 | — | — | WO | disclosed |
| WO-2012051663-A1 | ANTIMICROBIAL COMPOUNDS | MONASH UNIVERSITY (AU) | 2012-04-26 | — | — | WO | disclosed |
| WO-2010130007-A1 | ANTIMICROBIAL COMPOUNDS | MONASH UNIVERSITY (AU) | 2010-11-18 | — | — | WO | disclosed |