SCHEMBL2721174

SCHEMBL2721174

CCN(Cc1cccs1)C(=O)C=Cc1ccccc1C#N

nearest known ligand 0.60

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
▸ TRPM8 Q7Z2W7 12/20 0.60
▸ ALDH1A1 P00352 2/20 0.48
▸ L3MBTL1 Q9Y468 2/20 0.48
▸ HTT P42858 1/20 0.48
▸ NPC1 O15118 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30582794 1.00 TRPM8 (0.60) TRPM8ALDH1A1L3MBTL1HTTNPC1
SCHEMBL2721170 1.00 TRPM8 (0.60) TRPM8ALDH1A1L3MBTL1HTTNPC1
SCHEMBL30582821 0.84 TRPM8 (0.65) TRPM8ALDH1A1L3MBTL1HTTNPC1
SCHEMBL2717635 0.84 TRPM8 (0.65) TRPM8ALDH1A1L3MBTL1HTTNPC1
SCHEMBL2720009 0.84 TRPM8 (0.69) TRPM8ALDH1A1L3MBTL1HTTNPC1
SCHEMBL2720006 0.84 TRPM8 (0.69) TRPM8ALDH1A1L3MBTL1HTTNPC1
SCHEMBL2717637 0.84 TRPM8 (0.65) TRPM8ALDH1A1L3MBTL1HTTNPC1
SCHEMBL2716660 0.81 TRPM8 (0.75) TRPM8L3MBTL1NPC1
SCHEMBL2716656 0.81 TRPM8 (0.75) TRPM8L3MBTL1NPC1
SCHEMBL2720105 0.81 TRPM8 (0.61) TRPM8ALDH1A1L3MBTL1HTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2025132323-A1 COMPOSITIONS COMPRISING A SUNSCREEN ACTIVE AGENT DSM-FIRMENICH AG (CH) 2025-06-26 — — WO disclosed
EP-3470407-B1 COMPOUNDS USEFUL AS MODULATORS OF TRPM8 FIRMENICH INCORPORATED (US) 2024-01-24 — — EP disclosed
EP-3478089-B1 PLATED YEAST FORMULATIONS FIRMENICH & CIE (CH) 2021-11-03 — — EP disclosed
US-11160894-B2 Perfume emanating device FIRMENICH SA (CH) 2021-11-02 — — US disclosed
US-11091734-B2 Plated yeast formulations FIRMENICH SA (CH) 2021-08-17 — — US disclosed
US-10953007-B2 Compounds useful as modulators of TRPM8 FIRMENICH INCORPORATED (US) 2021-03-23 — — US disclosed
EP-3478089-A1 PLATED YEAST FORMULATIONS Firmenich SA (CH) 2019-05-08 — — EP disclosed
EP-3470407-A1 COMPOUNDS USEFUL AS MODULATORS OF TRPM8 Senomyx, Inc. (US) 2019-04-17 — — EP disclosed
EP-2635572-B1 COMPOUNDS USEFUL AS MODULATORS OF TRPM8 SENOMYX INC (US) 2018-10-17 — — EP disclosed
US-20180289704-A1 COMPOUNDS USEFUL AS MODULATORS OF TRPM8 FIRMENICH INCORPORATED 2018-10-11 — — US disclosed
US-20180264156-A1 PERFUME EMANATING DEVICE FIRMENICH SA (CH) 2018-09-20 — — US disclosed
EP-3355944-A1 PERFUME EMANATING DEVICE Firmenich SA (CH) 2018-08-08 — — EP disclosed
US-10016418-B2 Compounds useful as modulators of TRPM8 Seaomyx, Inc. (US) 2018-07-10 — — US disclosed
WO-2018002331-A1 PLATED YEAST FORMULATIONS FIRMENICH SA (CH) 2018-01-04 — — WO disclosed
US-20160317532-A1 COMPOUNDS USEFUL AS MODULATORS OF TRPM8 FIRMENICH INCORPORATED 2016-11-03 — — US disclosed
US-9394287-B2 Compounds useful as modulators of TRPM8 SENOMYX, INC. (US) 2016-07-19 — — US disclosed
US-20130324557-A1 COMPOUNDS USEFUL AS MODULATORS OF TRPM8 SENOMYX, INC. (US) 2013-12-05 — — US disclosed
EP-2635572-A2 COMPOUNDS USEFUL AS MODULATORS OF TRPM8 Senomyx, Inc. (US) 2013-09-11 — — EP disclosed
WO-2012061698-A9 COMPOUNDS USEFUL AS MODULATORS OF TRPM8 SENOMYX, INC. (US) 2012-09-13 — — WO disclosed
WO-2012061698-A2 COMPOUNDS USEFUL AS MODULATORS OF TRPM8 SENOMYX, INC. (US) 2012-05-10 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11160894-B2 Perfume emanating device DPM1, SURF4, FAAH2 TRPM8 151/4885ALDH1A1 646/4885L3MBTL1 4084/4885
US-10953007-B2 Compounds useful as modulators of TRPM8 TRPM8, TRPM7, TRPM6 TRPM8 1/4885ALDH1A1 1409/4885L3MBTL1 4024/4885
US-10016418-B2 Compounds useful as modulators of TRPM8 TRPM8, TRPM7, TRPM6 TRPM8 1/4885ALDH1A1 1409/4885L3MBTL1 4024/4885
US-20180264156-A1 PERFUME EMANATING DEVICE DPM1, SURF4, FAAH2 TRPM8 151/4885ALDH1A1 646/4885L3MBTL1 4084/4885
US-20160317532-A1 COMPOUNDS USEFUL AS MODULATORS OF TRPM8 TRPM8, TRPM7, TRPM6 TRPM8 1/4885ALDH1A1 1409/4885L3MBTL1 4024/4885
US-20130324557-A1 COMPOUNDS USEFUL AS MODULATORS OF TRPM8 TRPM8, TRPM7, TRPM6 TRPM8 1/4885ALDH1A1 1409/4885L3MBTL1 4024/4885
US-20180289704-A1 COMPOUNDS USEFUL AS MODULATORS OF TRPM8 TRPM8, TRPM7, TRPM6 TRPM8 1/4885ALDH1A1 1409/4885L3MBTL1 4024/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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