SCHEMBL27214060

SCHEMBL27214060

COc1ccc(C(NC(=O)OCC2c3ccccc3-c3ccccc32)c2ccc(OCC(=O)NC(c3ccccc3)c3ccc(C)cc3)cc2)c(OC)c1

nearest known ligand 0.54

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
▸ KMT2A Q03164 5/20 0.54
▸ MEN1 O00255 4/20 0.54
▸ ALDH1A1 P00352 2/20 0.45
▸ MAPT P10636 2/20 0.45
▸ HPGD P15428 2/20 0.45
▸ HTT P42858 2/20 0.45
▸ SMN1; SMN2 Q16637 2/20 0.45
▸ LMNA P02545 1/20 0.45
▸ ADAMTS5 Q9UNA0 6/20 0.45
▸ POLB P06746 1/20 0.44
▸ NPC1 O15118 2/20 0.43
▸ RAB9A P51151 1/20 0.43
▸ MDM2 Q00987 2/20 0.41
▸ TP53 P04637 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31749265 1.00 KMT2A (0.54) KMT2AMEN1ALDH1A1MAPTHPGD
SCHEMBL14007040 0.98 KMT2A (0.51) KMT2AMEN1ALDH1A1MAPTHPGD
SCHEMBL20586242 0.94 KMT2A (0.48) KMT2AMEN1ALDH1A1MAPTHPGD
SCHEMBL21096853 0.91 MEN1 (0.44) KMT2AMEN1ALDH1A1MAPTHPGD
SCHEMBL14450381 0.91 KMT2A (0.46) KMT2AMEN1ALDH1A1MAPTHPGD
SCHEMBL25446265 0.91 MEN1 (0.44) KMT2AMEN1ALDH1A1MAPTHPGD
SCHEMBL24510299 0.91 MEN1 (0.44) KMT2AMEN1ALDH1A1MAPTHPGD
SCHEMBL25855706 0.91 MEN1 (0.44) KMT2AMEN1ALDH1A1MAPTHPGD
SCHEMBL13227693 0.90 KMT2A (0.45) KMT2AMEN1ALDH1A1MAPTHPGD
SCHEMBL12972568 0.90 MEN1 (0.45) KMT2AMEN1ALDH1A1MAPTHPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250325683-A1 LONG-ACTING DUAL GIP/GLP-1 PEPTIDE CONJUGATES AND METHODS OF USE SCRIPPS RESEARCH INST (US) 2025-10-23 — — US disclosed
US-20250320252-A1 LONG-ACTING DUAL GIP/GLP-1 PEPTIDE CONJUGATES AND METHODS OF USE SCRIPPS RESEARCH INST (US) 2025-10-16 — — US disclosed
US-12329823-B2 Long-acting dual GIP/GLP-1 peptide conjugates and methods of use THE SCRIPPS RESEARCH INSTITUTE (US) 2025-06-17 — — US disclosed
US-20240148884-A1 LONG-ACTING DUAL GIP/GLP-1 PEPTIDE CONJUGATES AND METHODS OF USE THE SCRIPPS RESEARCH INSTITUTE 2024-05-09 — — US disclosed
CN-109153703-B Immunomodulator 百时美施贵宝公司 2022-09-23 — — CN disclosed
CN-107207568-B Immunomodulator 百时美施贵宝公司 2021-12-10 — — CN disclosed
CN-107001424-B Immunomodulator 百时美施贵宝公司 2021-03-05 — — CN disclosed
CN-111051332-A Immunomodulator 百时美施贵宝公司 2020-04-21 — — CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240148884-A1 LONG-ACTING DUAL GIP/GLP-1 PEPTIDE CONJUGATES AND METHODS OF USE GLP1R, GIPR, GCGR KMT2A 2554/4885MEN1 1457/4885ALDH1A1 2672/4885
US-20250325683-A1 LONG-ACTING DUAL GIP/GLP-1 PEPTIDE CONJUGATES AND METHODS OF USE GLP1R, GIPR, GCGR KMT2A 2554/4885MEN1 1457/4885ALDH1A1 2672/4885
US-12329823-B2 Long-acting dual GIP/GLP-1 peptide conjugates and methods of use GLP1R, GIPR, GCGR KMT2A 2554/4885MEN1 1457/4885ALDH1A1 2672/4885
US-20250320252-A1 LONG-ACTING DUAL GIP/GLP-1 PEPTIDE CONJUGATES AND METHODS OF USE GLP1R, GIPR, GCGR KMT2A 2554/4885MEN1 1457/4885ALDH1A1 2672/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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