SCHEMBL27214764

SCHEMBL27214764

Fc1cc(F)cc(C#Cc2cc(F)cc(F)c2)c1

nearest known ligand 0.64

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
GRM5 P41594 2/20 0.48
CA12 O43570 2/20 0.42
CA1 P00915 2/20 0.42
CA9 Q16790 2/20 0.42
CES2 O00748 1/20 0.36
CES1 P23141 1/20 0.36
CHRNB2 P17787 1/20 0.35
CHRNA4 P43681 1/20 0.35
CA2 P00918 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6369908 0.84 APP (0.60) GRM5CA12CA1CA9CA2
SCHEMBL8005775 0.82 GRM5 (0.42) GRM5CA12CA1CA9CES2
SCHEMBL21727247 0.82 GRM5 (0.38) GRM5CA12CA1CA9CES2
SCHEMBL20813871 0.80 GRM5 (0.47) GRM5CA12CA1CA9CA2
SCHEMBL4457929 0.80 GRM5 (0.56) GRM5
SCHEMBL6786135 0.76 ALDH1A1 (0.38) GRM5CA12CA1CA9CES2
SCHEMBL8303950 0.76 GRM5 (0.35) GRM5CA12CA1CA9
SCHEMBL852757 0.76 GRM5 (0.43) GRM5CA12CA1CA9
SCHEMBL19578703 0.76 GRM5 (0.39) GRM5CA12CA1CA9
SCHEMBL449836 0.76

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240151993-A1 ELECTRON WITHDRAWING GROUP (EWG)-CONTAINING ORGANIC MOLECULES FOR IMPROVED OPTICAL PROPERTIES IN AR/VR COMPONENTS META PLATFORMS TECHNOLOGIES, LLC 2024-05-09 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240151993-A1 ELECTRON WITHDRAWING GROUP (EWG)-CONTAINING ORGANIC MOLECULES FOR IMPROVED OPTICAL PROPERTIES IN AR/VR COMPONENTS AR, OR10J3, ESRRG GRM5 548/4885CA12 1442/4885CA1 2106/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.