Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BLM | P54132 | 3/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.67 |
| ▸ | LMNA | P02545 | 3/20 | 0.67 |
| ▸ | TSHR | P16473 | 3/20 | 0.67 |
| ▸ | PMP22 | Q01453 | 3/20 | 0.67 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.67 |
| ▸ | MAPT | P10636 | 3/20 | 0.67 |
| ▸ | NFKB1 | P19838 | 3/20 | 0.67 |
| ▸ | HTR1A | P08908 | 3/20 | 0.67 |
| ▸ | HTR2A | P28223 | 3/20 | 0.67 |
| ▸ | HTR2C | P28335 | 3/20 | 0.67 |
| ▸ | HTR2B | P41595 | 3/20 | 0.67 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.67 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.67 |
| ▸ | HTR7 | P34969 | 2/20 | 0.67 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.67 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.67 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.67 |
| ▸ | MTOR | P42345 | 1/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19357216 | 0.94 | HTR2C (0.76) | BLMKMT2ALMNATSHRPMP22 | |
| SCHEMBL475351 | 0.90 | MAPT (0.74) | BLMKMT2ALMNATSHRPMP22 | |
| SCHEMBL289044 | 0.90 | MAPT (0.74) | BLMKMT2ALMNATSHRPMP22 | |
| SCHEMBL10359013 | 0.88 | TACR1 (0.62) | BLMKMT2ALMNATSHRPMP22 | |
| SCHEMBL243575 | 0.88 | TACR1 (0.62) | BLMKMT2ALMNATSHRPMP22 | |
| Oxitriptan SCHEMBL30209795 | 0.88 | KMT2A (0.88) | BLMKMT2ALMNATSHRPMP22 | |
| Oxitriptan SCHEMBL4063333 | 0.88 | KMT2A (0.88) | BLMKMT2ALMNATSHRPMP22 | |
| Oxitriptan SCHEMBL2721519 | 0.88 | KMT2A (0.88) | BLMKMT2ALMNATSHRPMP22 | |
| Oxitriptan SCHEMBL7721883 | 0.88 | KMT2A (0.88) | BLMKMT2ALMNATSHRPMP22 | |
| Oxitriptan SCHEMBL5921917 | 0.88 | KMT2A (0.88) | BLMKMT2ALMNATSHRPMP22 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2629615-A1 | SLOW-RELEASE FORMULATIONS OF 5-HYDROXYTRYPTOPHAN AS AN ADJUNCT TO PRO-SEROTONERGIC THERAPIES | Duke University (US) | 2013-08-28 | — | — | EP | disclosed |
| WO-2012054815-A1 | SLOW-RELEASE FORMULATIONS OF 5-HYDROXYTRYPTOPHAN AS AN ADJUNCT TO PRO-SEROTONERGIC THERAPIES | DUKE UNIVERSITY (US) | 2012-04-26 | — | — | WO | disclosed |
| EP-2028935-A2 | ADMINISTRATION OF DOPA PRECURSORS WITH SOURCES OF DOPA TO EFFECTUATE OPTIMAL CATECHOLAMINE NEUROTRANSMITTER OUTCOMES | Neuroresearch, Inc. (US) | 2009-03-04 | — | — | EP | disclosed |
| WO-2007146174-A2 | ADMINISTRATION OF DOPA PRECURSORS WITH SOURCES OF DOPA TO EFFECTUATE OPTIMAL CATECHOLAMINE NEUROTRANSMITTER OUTCOMES | NEURORESEARCH, INC. (US) | 2007-12-21 | — | — | WO | disclosed |
| US-20060040003-A1 | Dietary supplement for supressing appetite, enhancing and extending satiety, improving glycemic control, and stimulant free | NEEDLEMAN ALVIN | 2006-02-23 | — | — | US | disclosed |
| EP-0074909-A1 | Compositions on the basis of 5-hydroxy-tryptophane, manufacturing process and medicaments containing them | S.A. PANMEDICA Société dite: (FR) | 1983-03-23 | — | — | EP | disclosed |