SCHEMBL27216342

SCHEMBL27216342

CC(C)(C)C(NC(=O)C(F)(F)F)C(=O)N1C[C@H]2[C@@H]([C@H]1C(=O)NC(C#N)c1cncc(C(F)(F)F)c1)C2(C)C

nearest known ligand 0.58

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
CTSV O60911 1/20 0.55
CYP3A4 P08684 1/20 0.55
CTSS P25774 1/20 0.55
CTSK P43235 1/20 0.55

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27216337 1.00 CTSV (0.55) CTSVCYP3A4CTSSCTSK
SCHEMBL30935101 1.00 CTSV (0.55) CTSVCYP3A4CTSSCTSK
SCHEMBL24996608 0.93 CTSV (0.47) CTSVCYP3A4CTSSCTSK
SCHEMBL30966553 0.92 CTSV (0.55) CTSVCYP3A4CTSSCTSK
SCHEMBL30934998 0.91 CTSV (0.45) CTSVCYP3A4CTSSCTSK
SCHEMBL30966533 0.91 CTSV (0.55) CTSVCYP3A4CTSSCTSK
SCHEMBL30236943 0.91 CTSV (0.57) CTSVCYP3A4CTSSCTSK
SCHEMBL30237697 0.91 CTSV (0.55) CTSVCYP3A4CTSSCTSK
SCHEMBL27216376 0.91 CTSV (0.57) CTSVCYP3A4CTSSCTSK
SCHEMBL27216377 0.91 CTSV (0.57) CTSVCYP3A4CTSSCTSK

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4368610-A1 3CL PROTEASE SMALL-MOLECULE INHIBITOR FOR TREATING OR PREVENTING CORONAVIRUS INFECTION, AND USE THEREOF The Global Health Drug Discovery Institute (CN) 2024-05-15 EP disclosed