Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 20/20 | 0.57 |
| ▸ | HTR7 | P34969 | 2/20 | 0.49 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.49 |
| ▸ | HTR1A | P08908 | 1/20 | 0.48 |
| ▸ | HTR2C | P28335 | 1/20 | 0.48 |
| ▸ | HTR2B | P41595 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL9108834 | 0.99 | HTR6 (0.56) | HTR6HTR7HTR4HTR1AHTR2C | |
| SCHEMBL4549896 | 0.89 | HTR6 (0.73) | HTR6HTR7HTR4HTR1AHTR2C | |
| SCHEMBL4550033 | 0.89 | TSHR (0.48) | HTR6 | |
| Hydrochloric Acid SCHEMBL2719620 | 0.88 | HTR6 (0.72) | HTR6HTR7HTR4HTR1AHTR2C | |
| Hydrochloric Acid SCHEMBL9111196 | 0.88 | RAD52 (0.49) | HTR6 | |
| SCHEMBL2720305 | 0.86 | HTR6 (0.62) | HTR6HTR7HTR4HTR1AHTR2C | |
| SCHEMBL2719696 | 0.82 | GFER (0.46) | HTR6 | |
| SCHEMBL4550065 | 0.81 | HTR6 (0.58) | HTR6 | |
| SCHEMBL6186705 | 0.80 | HTR6 (0.76) | HTR6HTR7HTR4HTR1AHTR2C | |
| Hydrochloric Acid SCHEMBL2721358 | 0.80 | HTR6 (0.57) | HTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8710059-B2 | N-phenyl-(homo)piperazinyl-benzenesulfonyl or benzenesulfonamide compounds suitable for treating disorders that respond to the modulation of the serotonin 5-HT6 receptor | ABBOTT LABORATORIES (US) | 2014-04-29 | — | — | US | disclosed |
| US-8710059-B2 | N-phenyl-(homo)piperazinyl-benzenesulfonyl or benzenesulfonamide compounds suitable for treating disorders that respond to the modulation of the serotonin 5-HT6 receptor | ABBOTT LABORATORIES (US) | 2014-04-29 | — | — | US | disclosed |
| US-20120142674-A1 | N-PHENYL-(HOMO)PIPERAZINYL-BENZENESULFONYL OR BENZENESULFONAMIDE COMPOUNDS SUITABLE FOR TREATING DISORDERS THAT RESPOND TO THE MODULATION OF THE SEROTONIN 5-HT6 RECEPTOR | ABBOTT LABORATORIES (US) | 2012-06-07 | — | — | US | disclosed |
| US-20120142674-A1 | N-PHENYL-(HOMO)PIPERAZINYL-BENZENESULFONYL OR BENZENESULFONAMIDE COMPOUNDS SUITABLE FOR TREATING DISORDERS THAT RESPOND TO THE MODULATION OF THE SEROTONIN 5-HT6 RECEPTOR | ABBOTT LABORATORIES (US) | 2012-06-07 | — | — | US | disclosed |
| WO-2012059432-A1 | N-PHENYL-(HOMO)PIPERAZINYL-BENZENESULFONYL OR BENZENESULFONAMIDE COMPOUNDS SUITABLE FOR TREATING DISORDERS THAT RESPOND TO THE MODULATION OF THE 5-HT6 RECEPTOR | ABBOTT GMBH & CO. KG (DE) | 2012-05-10 | — | — | WO | disclosed |
| WO-2012059432-A1 | N-PHENYL-(HOMO)PIPERAZINYL-BENZENESULFONYL OR BENZENESULFONAMIDE COMPOUNDS SUITABLE FOR TREATING DISORDERS THAT RESPOND TO THE MODULATION OF THE 5-HT6 RECEPTOR | ABBOTT GMBH & CO. KG (DE) | 2012-05-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120142674-A1 | N-PHENYL-(HOMO)PIPERAZINYL-BENZENESULFONYL OR BENZENESULFONAMIDE COMPOUNDS SUITABLE FOR TREATING DISORDERS THAT RESPOND TO THE MODULATION OF THE SEROTONIN 5-HT6 RECEPTOR | HTR6, HTR5A, HTR1B | HTR6 1/4885HTR7 10/4885HTR4 4/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.