Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 4/20 | 0.51 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.50 |
| ▸ | APP | P05067 | 3/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.50 |
| ▸ | PTGS1 | P23219 | 4/20 | 0.49 |
| ▸ | PGR | P06401 | 1/20 | 0.49 |
| ▸ | PDE4A | P27815 | 1/20 | 0.49 |
| ▸ | AKR1C3 | P42330 | 4/20 | 0.49 |
| ▸ | AKR1C2 | P52895 | 4/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | FABP2 | P12104 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.49 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.49 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.49 |
| ▸ | HTR2C | P28335 | 1/20 | 0.49 |
| ▸ | DRD3 | P35462 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1543120 | 0.81 | LMNA (0.74) | MAOBPTGS2APPCYP2C19PTGS1 | |
| SCHEMBL8755498 | 0.81 | LMNA (0.74) | MAOBPTGS2APPCYP2C19PTGS1 | |
| SCHEMBL8755392 | 0.81 | LMNA (0.74) | MAOBPTGS2APPCYP2C19PTGS1 | |
| SCHEMBL13448835 | 0.81 | LMNA (0.74) | MAOBPTGS2APPCYP2C19PTGS1 | |
| SCHEMBL1543413 | 0.81 | LMNA (0.74) | MAOBPTGS2APPCYP2C19PTGS1 | |
| SCHEMBL24177869 | 0.81 | CYP2C19 (0.61) | MAOBPTGS2APPCYP2C19PTGS1 | |
| SCHEMBL4217335 | 0.81 | LMNA (0.74) | MAOBPTGS2APPCYP2C19PTGS1 | |
| SCHEMBL8755011 | 0.81 | LMNA (0.74) | MAOBPTGS2APPCYP2C19PTGS1 | |
| SCHEMBL25873290 | 0.80 | MAOB (0.62) | MAOBPTGS2APPCYP2C19PTGS1 | |
| Hydrochloric Acid SCHEMBL27850094 | 0.80 | LMNA (0.72) | MAOBPTGS2APPCYP2C19PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12577245-B2 | Sulfonyl benzamide derivatives as Bcl-2 inhibitors | ASCENTAGE PHARMA (SUZHOU) CO., LTD. (CN) | 2026-03-17 | — | — | US | disclosed |
| US-20240166644-A1 | SULFONYL BENZAMIDE DERIVATIVES AS BCL-2 INHIBITORS | ASCENTAGE PHARMA GROUP CORP LIMITED (CN) | 2024-05-23 | — | — | US | disclosed |
| CN-114835704-B | Sulfonylbenzamide derivatives as BCL-2 inhibitors | 苏州亚盛药业有限公司 | 2023-10-27 | — | — | CN | disclosed |
| CN-114835704-A | Sulfonylbenzamide derivatives as BCL-2 inhibitors | 苏州亚盛药业有限公司 | 2022-08-02 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12577245-B2 | Sulfonyl benzamide derivatives as Bcl-2 inhibitors | BCL2A1, BCL2L1, BCL2L11 | MAOB 3426/4885PTGS2 2422/4885APP 3442/4885 |
| US-20240166644-A1 | SULFONYL BENZAMIDE DERIVATIVES AS BCL-2 INHIBITORS | BCL2, BCL2L2, BCL2L1 | MAOB 3174/4885PTGS2 1531/4885APP 1172/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.