Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPC1 | P48995 | 2/20 | 0.64 |
| ▸ | TRPC3 | Q13507 | 2/20 | 0.64 |
| ▸ | STIM1 | Q13586 | 2/20 | 0.64 |
| ▸ | ORAI1 | Q96D31 | 2/20 | 0.64 |
| ▸ | STIM2 | Q9P246 | 2/20 | 0.64 |
| ▸ | MAPT | P10636 | 7/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.53 |
| ▸ | HPGD | P15428 | 7/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | GAA | P10253 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 2/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21419596 | 0.89 | TRPC1 (0.68) | TRPC1TRPC3STIM1ORAI1STIM2 | |
| SCHEMBL1194642 | 0.88 | TRPC1 (0.67) | TRPC1TRPC3STIM1ORAI1STIM2 | |
| SCHEMBL8345184 | 0.88 | TRPC1 (0.67) | TRPC1TRPC3STIM1ORAI1STIM2 | |
| SCHEMBL5533620 | 0.87 | TRPC1 (0.66) | TRPC1TRPC3STIM1ORAI1STIM2 | |
| SCHEMBL2325526 | 0.87 | MAPT (0.76) | TRPC1TRPC3STIM1ORAI1STIM2 | |
| SCHEMBL19692480 | 0.87 | TRPC1 (0.66) | TRPC1TRPC3STIM1ORAI1STIM2 | |
| SCHEMBL19692293 | 0.87 | TRPC1 (0.72) | TRPC1TRPC3STIM1ORAI1STIM2 | |
| SCHEMBL19692277 | 0.87 | TRPC1 (0.72) | TRPC1TRPC3STIM1ORAI1STIM2 | |
| SCHEMBL1814204 | 0.86 | ALDH1A1 (0.67) | TRPC1TRPC3STIM1ORAI1STIM2 | |
| SCHEMBL21605139 | 0.86 | TRPC1 (0.59) | TRPC1TRPC3STIM1ORAI1STIM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2632269-A1 | CYCLIC AMINE SUBSTITUTED OXAZOLIDINONE CETP INHIBITOR | Merck Sharp & Dohme Corp. (US) | 2013-09-04 | — | — | EP | disclosed |
| WO-2012058187-A1 | CYCLIC AMINE SUBSTITUTED OXAZOLIDINONE CETP INHIBITOR | MERCK SHARP & DOHME CORP. (US) | 2012-05-03 | — | — | WO | disclosed |