SCHEMBL1194642

SCHEMBL1194642

CCOC(=O)c1cnn(-c2ccc(F)cc2)c1C(F)(F)F

nearest known ligand 0.67

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TRPC1 P48995 2/20 0.67
TRPC3 Q13507 2/20 0.67
STIM1 Q13586 2/20 0.67
ORAI1 Q96D31 2/20 0.67
STIM2 Q9P246 2/20 0.67
ALDH1A1 P00352 10/20 0.66
HPGD P15428 7/20 0.66
KDM4E B2RXH2 7/20 0.66
CYP1A2 P05177 2/20 0.66
CYP2C9 P11712 2/20 0.66
CYP2C19 P33261 2/20 0.66
MAPT P10636 7/20 0.62
GAA P10253 3/20 0.58
L3MBTL1 Q9Y468 4/20 0.57
MEN1 O00255 2/20 0.57
KMT2A Q03164 2/20 0.57
TDP1 Q9NUW8 1/20 0.55
RAB9A P51151 2/20 0.55
POLB P06746 2/20 0.55
SMN1; SMN2 Q16637 4/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21419596 0.91 TRPC1 (0.68) TRPC1TRPC3STIM1ORAI1STIM2
SCHEMBL8345184 0.90 TRPC1 (0.67) TRPC1TRPC3STIM1ORAI1STIM2
SCHEMBL2325526 0.89 MAPT (0.76) TRPC1TRPC3STIM1ORAI1STIM2
SCHEMBL5533620 0.89 TRPC1 (0.66) TRPC1TRPC3STIM1ORAI1STIM2
SCHEMBL19692480 0.89 TRPC1 (0.66) TRPC1TRPC3STIM1ORAI1STIM2
SCHEMBL1814204 0.89 ALDH1A1 (0.67) TRPC1TRPC3STIM1ORAI1STIM2
SCHEMBL12931795 0.88 TRPC1 (0.66) TRPC1TRPC3STIM1ORAI1STIM2
SCHEMBL2722465 0.88 TRPC1 (0.64) TRPC1TRPC3STIM1ORAI1STIM2
SCHEMBL21604763 0.88 TRPC1 (0.64) TRPC1TRPC3STIM1ORAI1STIM2
SCHEMBL23510303 0.87 TRPC1 (0.60) TRPC1TRPC3STIM1ORAI1STIM2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260132158-A1 PHENYL OXY AMIDE KINASE INHIBITORS THE TRANSLATIONAL GENOMICS RESEARCH INST (US) 2026-05-14 US disclosed
EP-4735430-A1 MALT1 INHIBITORS Janssen Pharmaceutica NV (BE) 2026-05-06 EP disclosed
WO-2025003414-A1 MALT1 INHIBITORS JANSSEN PHARMACEUTICA NV (BE) 2025-01-02 WO disclosed
WO-2024077057-A1 PHENYL OXY AMIDE KINASE INHIBITORS THE TRANSLATIONAL GENOMICS RESEARCH INSTITUTE (US) 2024-04-11 WO disclosed
EP-2668182-B1 IL17 AND IFN-GAMMA INHIBITION FOR THE TREATMENT OF AUTOIMMUNE INFLAMMATION 4SC DISCOVERY GMBH (DE) 2017-11-01 EP disclosed
EP-2668182-B1 IL17 AND IFN-GAMMA INHIBITION FOR THE TREATMENT OF AUTOIMMUNE INFLAMMATION 4SC DISCOVERY GMBH (DE) 2017-11-01 EP disclosed
EP-2668183-B1 IL17 AND IFN-GAMMA INHIBITION FOR THE TREATMENT OF AUTOIMMUNE INFLAMMATION 4SC DISCOVERY GMBH (DE) 2017-11-01 EP disclosed
EP-2668183-B1 IL17 AND IFN-GAMMA INHIBITION FOR THE TREATMENT OF AUTOIMMUNE INFLAMMATION 4SC DISCOVERY GMBH (DE) 2017-11-01 EP disclosed
EP-2668182-A1 IL17 AND IFN-GAMMA INHIBITION FOR THE TREATMENT OF AUTOIMMUNE INFLAMMATION 4SC Discovery GmbH (DE) 2013-12-04 EP disclosed
US-8592456-B2 IL17 and IFN-gamma inhibition for the treatment of autoimmune inflammation 4SC DISCOVERY GMBH (DE) 2013-11-26 US disclosed
US-20120196862-A1 IL17 AND IFN-GAMMA INHIBITION FOR THE TREATMENT OF AUTOIMMUNE INFLAMMATION 4SC DISCOVERY GMBH (DE) 2012-08-02 US disclosed
US-20120196861-A1 IL17 AND IFN-GAMMA INHIBITION FOR THE TREATMENT OF AUTOIMMUNE INFLAMMATION 4SC DISCOVERY GMBH (DE) 2012-08-02 US disclosed
US-20120196862-A1 IL17 AND IFN-GAMMA INHIBITION FOR THE TREATMENT OF AUTOIMMUNE INFLAMMATION 4SC DISCOVERY GMBH (DE) 2012-08-02 US disclosed
EP-1904455-B1 PYRIDAZINE DERIVATIVES HOFFMANN LA ROCHE (CH) 2011-08-17 EP disclosed
EP-2155685-B1 PYRAZOLE DERIVATIVES AS P2X7 MODULATORS GLAXO GROUP LTD (GB) 2011-03-16 EP disclosed
US-20110046137-A1 Pyrazole Derivatives as P2X7 Modulators GLAXO GROUP LIMITED 2011-02-24 US disclosed
US-7678795-B2 Pyridazines as 11b-HSD1 inhibitors HOFFMAN-LA ROCHE INC. (US) 2010-03-16 US disclosed
EP-1904455-A2 PYRIDAZINE DERIVATIVES F. Hoffmann-Roche AG (CH) 2008-04-02 EP disclosed
US-20070010519-A1 New pyridazines as 11B-HSD1 inhibitors HOFFMANN-LA ROCHE INC. 2007-01-11 US disclosed
WO-2007003521-A2 PYRIDAZINE DERIVATIVES AS 11BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 INHIBITORS F. HOFFMANN-LA ROCHE AG (CH) 2007-01-11 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120196862-A1 IL17 AND IFN-GAMMA INHIBITION FOR THE TREATMENT OF AUTOIMMUNE INFLAMMATION IFNG, IL17A, IL2 TRPC1 3434/4885TRPC3 1512/4885STIM1 1505/4885
US-20120196861-A1 IL17 AND IFN-GAMMA INHIBITION FOR THE TREATMENT OF AUTOIMMUNE INFLAMMATION IFNG, IL17A, IL2 TRPC1 3434/4885TRPC3 1512/4885STIM1 1505/4885
US-20110046137-A1 Pyrazole Derivatives as P2X7 Modulators P2RX3, P2RX7, P2RX1 TRPC1 190/4885TRPC3 44/4885STIM1 395/4885
US-20070010519-A1 New pyridazines as 11B-HSD1 inhibitors HSD11B1, HSD17B1, HSD17B11 TRPC1 4047/4885TRPC3 4579/4885STIM1 3219/4885
US-20260132158-A1 PHENYL OXY AMIDE KINASE INHIBITORS RAF1, CNKSR1, PHKG1 TRPC1 3012/4885TRPC3 2602/4885STIM1 4728/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.