Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Fentanyl. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 known ✓ | P35372 | 10/20 | 0.74 |
| ▸ | OPRD1 | P41143 | 7/20 | 0.74 |
| ▸ | OPRK1 | P41145 | 5/20 | 0.74 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.74 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.74 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.74 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.74 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.74 |
| ▸ | DRD2 | P14416 | 1/20 | 0.74 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.74 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.74 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.74 |
| ▸ | MAOA | P21397 | 1/20 | 0.74 |
| ▸ | DRD4 | P21917 | 1/20 | 0.74 |
| ▸ | MAOB | P27338 | 1/20 | 0.74 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.74 |
| ▸ | HRH1 | P35367 | 1/20 | 0.74 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.74 |
| ▸ | DRD3 | P35462 | 1/20 | 0.74 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.74 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fentanyl SCHEMBL6908995 | 0.96 | OPRM1 (0.80) | OPRM1OPRD1OPRK1SIGMAR1SLC22A1 | |
| Fentanyl SCHEMBL6002326 | 0.96 | OPRM1 (0.80) | OPRM1OPRD1OPRK1SIGMAR1SLC22A1 | |
| Fentanyl SCHEMBL193602 | 0.96 | OPRM1 (0.80) | OPRM1OPRD1OPRK1SIGMAR1SLC22A1 | |
| Fentanyl SCHEMBL216836 | 0.96 | OPRM1 (0.80) | OPRM1OPRD1OPRK1SIGMAR1SLC22A1 | |
| Fentanyl SCHEMBL40733 | 0.96 | OPRM1 (0.80) | OPRM1OPRD1OPRK1SIGMAR1SLC22A1 | |
| Fentanyl SCHEMBL27481710 | 0.95 | OPRM1 (0.78) | OPRM1OPRD1OPRK1SIGMAR1SLC22A1 | |
| Fentanyl SCHEMBL19066928 | 0.95 | OPRM1 (0.78) | OPRM1OPRD1OPRK1SIGMAR1SLC22A1 | |
| Fentanyl SCHEMBL1773864 | 0.87 | OPRM1 (0.66) | OPRM1OPRD1OPRK1SIGMAR1SLC22A1 | |
| SCHEMBL9917098 | 0.86 | OPRM1 (0.87) | OPRM1OPRD1OPRK1SIGMAR1SLC22A1 | |
| SCHEMBL18609328 | 0.86 | OPRM1 (0.87) | OPRM1OPRD1OPRK1SIGMAR1SLC22A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025038661-A1 | OLIGONUCLEOTIDE SYNTHESIS METHODS | Arrowhead Pharmaceuticals, Inc. (US) | 2025-02-20 | — | — | WO | disclosed |
| US-8415138-B2 | Device for propagation of preferential oligomers and which utilizes mixtures of organic and protic solvents to detritylate nascent nucleotide sequences | AGILENT TECHNOLOGIES, INC. (US) | 2013-04-09 | — | — | US | disclosed |
| WO-2012059510-A1 | BACK PRESSURE CONTROL DURING SOLID-PHASE SYNTHESIS ON POLYMERIC SUPPORTS | GIRINDUS AMERICA, INC. (US) | 2012-05-10 | — | — | WO | disclosed |
| US-20080058512-A1 | APPARATUSES AND METHODS FOR OLIGONUCLEOTIDE PREPARATION | AGILENT TECHNOLOGIES, INC. | 2008-03-06 | — | — | US | disclosed |
| US-20080058511-A1 | METHODS AND COMPOSITIONS USEFUL IN THE PREPARATION OF OLIGONUCLEOTIDES | AGILENT TECHNOLOGIES, INC. | 2008-03-06 | — | — | US | disclosed |
| US-6538128-B1 | Efficient process for production of solid phase oligonucleotides; does not lead to channel current formation in polymer supports; disposable | AVECIA BIOTECHNOLOGY, INC. | 2003-03-25 | — | — | US | disclosed |