Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Fentanyl. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 known ✓ | P35372 | 9/20 | 0.80 |
| ▸ | OPRD1 | P41143 | 6/20 | 0.80 |
| ▸ | OPRK1 | P41145 | 5/20 | 0.80 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.80 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.80 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.80 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.80 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.80 |
| ▸ | DRD2 | P14416 | 1/20 | 0.80 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.80 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.80 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.80 |
| ▸ | MAOA | P21397 | 1/20 | 0.80 |
| ▸ | DRD4 | P21917 | 1/20 | 0.80 |
| ▸ | MAOB | P27338 | 1/20 | 0.80 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.80 |
| ▸ | HRH1 | P35367 | 1/20 | 0.80 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.80 |
| ▸ | DRD3 | P35462 | 1/20 | 0.80 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.80 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fentanyl SCHEMBL216836 | 1.00 | OPRM1 (0.80) | OPRM1OPRD1OPRK1SIGMAR1SLC22A1 | |
| Fentanyl SCHEMBL193602 | 1.00 | OPRM1 (0.80) | OPRM1OPRD1OPRK1SIGMAR1SLC22A1 | |
| Fentanyl SCHEMBL6002326 | 1.00 | OPRM1 (0.80) | OPRM1OPRD1OPRK1SIGMAR1SLC22A1 | |
| Fentanyl SCHEMBL6908995 | 1.00 | OPRM1 (0.80) | OPRM1OPRD1OPRK1SIGMAR1SLC22A1 | |
| Fentanyl SCHEMBL27481710 | 0.99 | OPRM1 (0.78) | OPRM1OPRD1OPRK1SIGMAR1SLC22A1 | |
| Fentanyl SCHEMBL19066928 | 0.99 | OPRM1 (0.78) | OPRM1OPRD1OPRK1SIGMAR1SLC22A1 | |
| Fentanyl SCHEMBL2722646 | 0.96 | OPRM1 (0.74) | OPRM1OPRD1OPRK1SIGMAR1SLC22A1 | |
| Fentanyl SCHEMBL1773864 | 0.91 | OPRM1 (0.66) | OPRM1OPRD1OPRK1SIGMAR1SLC22A1 | |
| Fentanyl SCHEMBL8804 | 0.89 | OPRM1 (1.00) | OPRM1OPRD1OPRK1SIGMAR1SLC22A1 | |
| Fentanyl SCHEMBL916599 | 0.89 | OPRM1 (1.00) | OPRM1OPRD1OPRK1SIGMAR1SLC22A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 11609 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12594281-B2 | Pharmaceutical dosage forms and methods of use | EMALEX BIOSCIENCES, INC. (US) | 2026-04-07 | — | — | US | claimed |
| US-12509465-B2 | Benzoimidazole derivatives as anticancer agents | CENTRE LEON BERARD (FR) | 2025-12-30 | — | — | US | claimed |
| US-20250295671-A1 | Hazardous Agent Injection System | ANTARES PHARMA, INC. (US) | 2025-09-25 | — | — | US | claimed |
| US-20250288594-A1 | PHARMACEUTICAL DOSAGE FORMS AND METHODS OF USE | EMALEX BIOSCIENCES, INC. | 2025-09-18 | — | — | US | claimed |
| US-12357642-B2 | Hazardous agent injection system | ANTARES PHARMA, INC. (US) | 2025-07-15 | — | — | US | claimed |
| US-20250205278-A1 | METHODS AND COMPOSITIONS FOR WOUND HEALING | ABBOTT NICHOLAS L (US) | 2025-06-26 | — | — | US | claimed |
| EP-4566675-A2 | HETEROCYCLIC COMPOUNDS AS IMMUNOMODULATORS | Incyte Corporation (US) | 2025-06-11 | — | — | EP | claimed |
| CN-119112837-B | Fentanyl citrate@PLGA-PEG nano microsphere and preparation method thereof | 中国人民解放军空军特色医学中心 | 2025-06-10 | — | — | CN | claimed |
| US-20250177358-A1 | COMBINATION OF SMALL MOLECULE CD-47 INHIBITORS WITH OTHER ANTI-CANCER AGENTS | AURIGENE DISCOVERY TECHNOLOGIES LIMITED (IN) | 2025-06-05 | — | — | US | claimed |
| WO-2025111413-A1 | TREATMENT FOR SKIN DISORDERS | Mycotechnology, Inc. (US) | 2025-05-30 | — | — | WO | claimed |
| EP-0543922-A4 | METHODS FOR INDUCING CELL DIFFERENTIATION USING CERAMIDES | — | 1993-07-28 | — | — | EP | claimed |
| EP-0543922-A1 | METHODS FOR INDUCING CELL DIFFERENTIATION USING CERAMIDES | DUKE UNIVERSITY (US) | 1993-06-02 | — | — | EP | claimed |
| WO-1993006820-A1 | HOLDER AND PACKAGING FOR A HARDENED MEDICATED MATRIX | ABBOTT LABORATORIES (US) | 1993-04-15 | — | — | WO | claimed |
| WO-1992003129-A1 | METHODS FOR INDUCING CELL DIFFERENTIATION USING CERAMIDES | DUKE UNIVERSITY (US) | 1992-03-05 | — | — | WO | claimed |
| EP-0452384-A1 | FENTANYL CONTAINING AEROSOL COMPOSITIONS. | RIKER LABORATORIES INC (US) | 1991-10-23 | — | — | EP | claimed |
| WO-1990007333-A1 | FENTANYL CONTAINING AEROSOL COMPOSITIONS | RIKER LABORATORIES, INC. (US) | 1990-07-12 | — | — | WO | claimed |
| US-4508715-A | DOPAMINE ANTAGONISTS;OVERDOSE TREATMENT | UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. (US) | 1985-04-02 | — | — | US | claimed |
| US-4486423-A | ACIDIC AQUEOUS CITRATE | JANSSEN PHARMACEUTICA INC. (US) | 1984-12-04 | — | — | US | claimed |
| EP-0105361-A1 | ANTAGONISM OF CENTRAL NERVOUS SYSTEM DRUGS BY THE ADMINISTRATION OF 4-AMINOPYRIDINE ALONE OR IN COMBINATION WITH OTHER DRUGS | THE UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. (US) | 1984-04-18 | — | — | EP | claimed |
| WO-1983003541-A1 | ANTAGONISM OF CENTRAL NERVOUS SYSTEM DRUGS BY THE ADMINISTRATION OF 4-AMINOPYRIDINE ALONE OR IN COMBINATION WITH OTHER DRUGS | UNIV GEORGIA RES FOUND (US) | 1983-10-27 | — | — | WO | claimed |