Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.45 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.45 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.45 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.45 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.44 |
| ▸ | TSPO | P30536 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.42 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2117209 | 0.82 | LMNA (0.62) | LMNANPC1RAB9ATDP1CHRM2 | |
| SCHEMBL24992390 | 0.81 | NPSR1 (0.44) | LMNANPC1RAB9ATDP1KMT2A | |
| SCHEMBL24992374 | 0.81 | NPSR1 (0.44) | LMNANPC1RAB9ATDP1KMT2A | |
| SCHEMBL7503719 | 0.81 | LMNA (0.50) | LMNANPC1RAB9ATDP1CHRM2 | |
| SCHEMBL11076827 | 0.77 | HPGD (0.51) | KMT2AMEN1ALDH1A1TSHR | |
| SCHEMBL3836681 | 0.77 | LMNA (0.72) | LMNANPC1CHRM2CHRM4CHRM5 | |
| SCHEMBL1059560 | 0.77 | LMNA (0.56) | LMNANPC1RAB9ATDP1CHRM2 | |
| SCHEMBL5497633 | 0.75 | ALDH1A1 (0.43) | NPC1RAB9AKMT2AALDH1A1TSHR | |
| SCHEMBL11378089 | 0.75 | LMNA (0.55) | LMNANPC1RAB9ATDP1CHRM2 | |
| SCHEMBL5073289 | 0.74 | TSHR (0.46) | NPC1RAB9AALDH1A1TSHRMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2445878-A1 | NEW COMPOUNDS, PHARMACEUTICAL COMPOSITION AND METHODS RELATING THERETO | Boehringer Ingelheim International GmbH (DE) | 2012-05-02 | — | — | EP | disclosed |
| WO-2010149684-A1 | NEW COMPOUNDS, PHARMACEUTICAL COMPOSITION AND METHODS RELATING THERETO | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-12-29 | — | — | WO | disclosed |