Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 2/20 | 0.45 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.45 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.45 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.45 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.38 |
| ▸ | SYK | P43405 | 7/20 | 0.38 |
| ▸ | CDK7 | P50613 | 2/20 | 0.37 |
| ▸ | CDK9 | P50750 | 2/20 | 0.37 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.37 |
| ▸ | CCNH | P51946 | 1/20 | 0.37 |
| ▸ | CDK13 | Q14004 | 1/20 | 0.34 |
| ▸ | CDK12 | Q9NYV4 | 1/20 | 0.34 |
| ▸ | JAK1 | P23458 | 1/20 | 0.34 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | SRC | P12931 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6890507 | 0.81 | CDK2 (0.48) | CDK2CHEK1CCNA2CCNA1PDE10A | |
| SCHEMBL10277723 | 0.81 | CDK2 (0.48) | CDK2CHEK1CCNA2CCNA1PDE10A | |
| SCHEMBL10236616 | 0.78 | CDK2 (0.49) | CDK2CHEK1CCNA2CCNA1PDE10A | |
| SCHEMBL1074061 | 0.74 | LGMN (0.40) | CDK2CHEK1CCNA2CCNA1JAK1 | |
| SCHEMBL2679820 | 0.71 | PDE10A (0.41) | CDK2CHEK1CCNA2CCNA1PDE10A | |
| SCHEMBL42979 | 0.71 | CDK2 (0.43) | CDK2CHEK1CCNA2CCNA1PDE10A | |
| SCHEMBL593655 | 0.71 | CDK2 (0.54) | CDK2CHEK1CCNA2CCNA1PDE10A | |
| SCHEMBL584858 | 0.70 | CHEK1 (0.59) | CDK2CHEK1CCNA2CCNA1PDE10A | |
| SCHEMBL2680236 | 0.69 | GPR119 (0.48) | CDK2CHEK1CCNA2CCNA1KDM4E | |
| SCHEMBL16104450 | 0.69 | SMN1; SMN2 (0.38) | SYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012027240-A1 | FUSED TRICYCLIC INHIBITORS OF MAMMALIAN TARGET OF RAPAMYCIN | SCHERING CORPORATION (US) | 2012-03-01 | — | — | WO | disclosed |