Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 2/20 | 0.59 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.59 |
| ▸ | CSF1R | P07333 | 14/20 | 0.56 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.52 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.46 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2723375 | 0.87 | KDM4E (0.59) | EGFRERBB2CSF1RPDE4BAURKB | |
| SCHEMBL2723483 | 0.85 | CSF1R (0.67) | EGFRERBB2CSF1RPDE4B | |
| SCHEMBL2723970 | 0.81 | CSF1R (0.58) | EGFRERBB2CSF1RPDE4B | |
| SCHEMBL2723611 | 0.77 | PDE4B (0.71) | EGFRERBB2CSF1RPDE4BAURKB | |
| SCHEMBL15054394 | 0.76 | AURKB (0.51) | EGFRERBB2CSF1RAURKB | |
| SCHEMBL2723683 | 0.76 | KDM4E (0.59) | CSF1RPDE4BAURKB | |
| SCHEMBL2723821 | 0.75 | CSF1R (0.58) | EGFRERBB2CSF1RPDE4B | |
| SCHEMBL15053963 | 0.75 | CSF1R (0.58) | EGFRERBB2CSF1RPDE4B | |
| SCHEMBL5929711 | 0.74 | EGFR (1.00) | EGFRERBB2CSF1R | |
| SCHEMBL15054323 | 0.74 | CSF1R (0.55) | EGFRERBB2CSF1RPDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2635279-A2 | CHEMICAL COMPOUNDS | Glaxosmithkline Intellectual Property (No. 2) Limited (GB) | 2013-09-11 | — | — | EP | disclosed |
| US-20130225524-A1 | Chemical Compounds | GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED (GB) | 2013-08-29 | — | — | US | disclosed |
| WO-2012061557-A2 | CHEMICAL COMPOUNDS | GLAXOSMITHKLINE LLC (US) | 2012-05-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130225524-A1 | Chemical Compounds | LDHA, NQO2, LDHB | EGFR 1772/4885ERBB2 1287/4885CSF1R 2683/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.