SCHEMBL27243764

SCHEMBL27243764

O=C(c1ccc(F)cc1)c1cnc(Cl)nc1Cl

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NPC1 O15118 2/20 0.47
RXFP1 Q9HBX9 1/20 0.47
LTA4H P09960 1/20 0.43
ABL1 P00519 1/20 0.43
BCR P11274 1/20 0.43
RAB9A P51151 1/20 0.42
SMN1; SMN2 Q16637 1/20 0.42
JUN P05412 1/20 0.42
NFKB1 P19838 1/20 0.42
NFKB2 Q00653 1/20 0.42
RELA Q04206 1/20 0.42
VNN1 O95497 1/20 0.42
KCNQ3 O43525 5/20 0.41
KCNQ2 O43526 5/20 0.41
KCNE1 P15382 3/20 0.41
KCNQ1 P51787 3/20 0.41
BACE1 P56817 1/20 0.41
KMT2A Q03164 2/20 0.40
MEN1 O00255 1/20 0.40
KCNQ5 Q9NR82 4/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5001988 0.83 AKR1C3 (0.44) NPC1RAB9ASMN1; SMN2JUNNFKB1
SCHEMBL4997555 0.82 KCNQ3 (0.53) NPC1RAB9ASMN1; SMN2JUNNFKB1
SCHEMBL25981388 0.78 NPC1 (0.59) NPC1RXFP1LTA4HRAB9ASMN1; SMN2
SCHEMBL30421262 0.77 NFKB1 (0.61) NPC1RAB9ASMN1; SMN2JUNNFKB1
SCHEMBL28557381 0.77 NFKB1 (0.61) NPC1RAB9ASMN1; SMN2JUNNFKB1
SCHEMBL2213903 0.77 LTA4H (0.46) NPC1RXFP1LTA4HRAB9ASMN1; SMN2
SCHEMBL5002132 0.76 ABL1 (0.45) ABL1BCRJUNNFKB1NFKB2
SCHEMBL17168048 0.75 SLC5A1 (0.43) NPC1RAB9AJUNNFKB1NFKB2
SCHEMBL5001832 0.75 CDK1 (0.45) SMN1; SMN2JUNNFKB1NFKB2RELA
SCHEMBL2214438 0.74 KCNQ3 (0.48) NPC1RXFP1LTA4HRAB9ASMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4598923-A1 SUPRAMOLECULAR POLYMER THERAPEUTICS AND DIAGNOSTICS The Regents of the University of California (US) 2025-08-13 EP disclosed
US-20240197682-A1 METHOD FOR TREATING NEUROLOGICAL DISEASES USING SUPRAMOLECULE POLYMER THERAPEUTICS THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2024-06-20 US disclosed
US-20240201205-A1 METHOD FOR DETECTING NEUROLOGICAL DISEASES USING SUPRAMOLECULE POLYMER THERAPEUTICS THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2024-06-20 US disclosed
US-20240199604-A1 SUPRAMOLECULAR POLYMER THERAPEUTICS AND DIAGNOSTICS THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2024-06-20 US disclosed
US-20240199604-A1 SUPRAMOLECULAR POLYMER THERAPEUTICS AND DIAGNOSTICS THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2024-06-20 US disclosed
US-20240199604-A1 SUPRAMOLECULAR POLYMER THERAPEUTICS AND DIAGNOSTICS THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2024-06-20 US disclosed
WO-2024059845-A1 SUPRAMOLECULAR POLYMER THERAPEUTICS AND DIAGNOSTICS THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2024-03-21 WO disclosed
WO-2024059845-A1 SUPRAMOLECULAR POLYMER THERAPEUTICS AND DIAGNOSTICS THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2024-03-21 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240199604-A1 SUPRAMOLECULAR POLYMER THERAPEUTICS AND DIAGNOSTICS MAPT, HTT, PSEN1 NPC1 256/4885RXFP1 3646/4885LTA4H 3045/4885
US-20240197682-A1 METHOD FOR TREATING NEUROLOGICAL DISEASES USING SUPRAMOLECULE POLYMER THERAPEUTICS PRNP, PSEN1, SNCA NPC1 1401/4885RXFP1 4429/4885LTA4H 4111/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.