Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 8/20 | 0.61 |
| ▸ | ADORA2B | P29275 | 5/20 | 0.61 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.57 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | NT5E | P21589 | 1/20 | 0.55 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2367601 | 1.00 | ADORA2A (0.61) | ADORA2AADORA2BADORA3ADORA1LMNA | |
| SCHEMBL1377204 | 1.00 | ADORA2A (0.61) | ADORA2AADORA2BADORA3ADORA1LMNA | |
| SCHEMBL271777 | 0.92 | ADORA2A (0.63) | ADORA2AADORA2BADORA3ADORA1 | |
| SCHEMBL271079 | 0.92 | ADORA2A (0.61) | ADORA2AADORA2BADORA3ADORA1LMNA | |
| SCHEMBL5386813 | 0.88 | ADORA3 (0.58) | ADORA2AADORA2BADORA3ADORA1 | |
| SCHEMBL3826172 | 0.86 | ADORA2A (0.63) | ADORA2AADORA2BADORA3ADORA1LMNA | |
| SCHEMBL5397271 | 0.84 | ADORA3 (0.60) | ADORA2AADORA2BADORA3ADORA1 | |
| SCHEMBL3949601 | 0.82 | ADORA1 (0.62) | ADORA2AADORA2BADORA3ADORA1NT5E | |
| SCHEMBL3947025 | 0.82 | ADORA1 (0.62) | ADORA2AADORA2BADORA3ADORA1NT5E | |
| SCHEMBL5034539 | 0.82 | ADORA1 (0.62) | ADORA2AADORA2BADORA3ADORA1NT5E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 57 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE47351-E1 | 2-(N-pyrazolo)adenosines with application as adenosine A2A receptor agonists | GILEAD SCIENCES, INC. (US) | 2019-04-16 | — | — | US | claimed |
| US-8569260-B2 | N-pyrazole A2A receptor agonists | GILEAD SCIENCES, INC. (US) | 2013-10-29 | — | — | US | claimed |
| US-20040038928-A1 | N-pyrazole A2A receptor agonists | CV THERAPEUTICS, INC. | 2004-02-26 | — | — | US | claimed |
| EP-1189916-B1 | N-PYRAZOLE A 2A RECEPTOR AGONISTS | CV THERAPEUTICS INC (US) | 2003-12-10 | — | — | EP | claimed |
| US-6642210-B1 | Administering compound to mammal by intravenous bolus injection to stress heart and induce coronary steal situation, stimulating coronary vasodilation, in order to image heart | CV THERAPEUTICS, INC. | 2003-11-04 | — | — | US | claimed |
| US-RE47351-E1 | 2-(N-pyrazolo)adenosines with application as adenosine A2A receptor agonists | GILEAD SCIENCES, INC. (US) | 2019-04-16 | — | — | US | disclosed |
| US-9289446-B2 | Myocardial perfusion imaging methods and compositions | GILEAD SCIENCES, INC. (US) | 2016-03-22 | — | — | US | disclosed |
| US-20160067271-A1 | Methods And Compositions For Preventing Or Treating Obesity | NORTHEASTERN UNIVERSITY | 2016-03-10 | — | — | US | disclosed |
| US-20150283162-A1 | MYOCARDIAL PERFUSION IMAGING METHODS AND COMPOSITIONS | GILEAD PALO ALTO, INC. | 2015-10-08 | — | — | US | disclosed |
| US-9045519-B2 | N-pyrazole A2A receptor agonists | GILEAD SCIENCES, INC. (US) | 2015-06-02 | — | — | US | disclosed |
| US-8906878-B2 | Myocardial perfusion imaging methods and compositions | GILEAD SCIENCES, INC. (US) | 2014-12-09 | — | — | US | disclosed |
| US-8883500-B2 | Method of preparing adenosine-resistant anti-tumor T lymphocytes for adoptive immunotherapy | NORTHEASTERN UNIVERSITY (US) | 2014-11-11 | — | — | US | disclosed |
| US-20040064039-A1 | Myocardial perfusion imaging method | CV THERAPEUTICS | 2004-04-01 | — | — | US | disclosed |
| US-20040038928-A1 | N-pyrazole A2A receptor agonists | CV THERAPEUTICS, INC. | 2004-02-26 | — | — | US | disclosed |
| WO-2004011010-A1 | MYOCARDIAL PERFUSION IMAGING USING A2A RECEPTOR AGONISTS | CV THERAPEUTICS, INC. (US) | 2004-02-05 | — | — | WO | disclosed |
| EP-1189916-B1 | N-PYRAZOLE A 2A RECEPTOR AGONISTS | CV THERAPEUTICS INC (US) | 2003-12-10 | — | — | EP | disclosed |
| US-6642210-B1 | Administering compound to mammal by intravenous bolus injection to stress heart and induce coronary steal situation, stimulating coronary vasodilation, in order to image heart | CV THERAPEUTICS, INC. | 2003-11-04 | — | — | US | disclosed |
| US-6403567-B1 | N-pyrazole A2A adenosine receptor agonists | CV THERAPEUTICS, INC. | 2002-06-11 | — | — | US | disclosed |
| EP-1189916-A2 | N-PYRAZOLE A 2A RECEPTOR AGONISTS | CV THERAPEUTICS, INC. (US) | 2002-03-27 | — | — | EP | disclosed |
| WO-2000078779-A2 | N-PYRAZOLE A2A RECEPTOR AGONISTS | CV THERAPEUTICS, INC. (US) | 2000-12-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150283162-A1 | MYOCARDIAL PERFUSION IMAGING METHODS AND COMPOSITIONS | ADORA2A, ADORA3, ADORA1 | ADORA2A 1/4885ADORA2B 4/4885ADORA3 2/4885 |
| US-20040038928-A1 | N-pyrazole A2A receptor agonists | ADORA2A, ADORA3, ADORA1 | ADORA2A 1/4885ADORA2B 5/4885ADORA3 2/4885 |
| US-20160067271-A1 | Methods And Compositions For Preventing Or Treating Obesity | ADORA2A, ADORA3, ADORA1 | ADORA2A 1/4885ADORA2B 5/4885ADORA3 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.