Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 6/20 | 0.59 |
| ▸ | CLK1 | P49759 | 4/20 | 0.59 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | KIF20A | O95235 | 9/20 | 0.43 |
| ▸ | TDO2 | P48775 | 2/20 | 0.42 |
| ▸ | F7 | P08709 | 1/20 | 0.40 |
| ▸ | F3 | P13726 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | NHERF1 | O14745 | 1/20 | 0.37 |
| ▸ | SNCA | P37840 | 1/20 | 0.37 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2727931 | 0.83 | DYRK1A (0.54) | DYRK1ACLK1HPGDKIF20ATDO2 | |
| SCHEMBL2724514 | 0.81 | DYRK1A (0.51) | DYRK1ACLK1KIF20ATDO2NR4A2 | |
| SCHEMBL2726861 | 0.78 | KIF20A (0.54) | DYRK1ACLK1KIF20A | |
| SCHEMBL2726532 | 0.78 | KIF20A (0.54) | DYRK1ACLK1KIF20A | |
| SCHEMBL19178547 | 0.77 | DYRK1A (0.47) | DYRK1ACLK1KIF20ANR4A2 | |
| SCHEMBL2726951 | 0.75 | DYRK1A (0.50) | DYRK1ACLK1KIF20ANR4A2 | |
| SCHEMBL2726290 | 0.75 | DYRK1A (1.00) | DYRK1ACLK1KIF20ATDO2MAPT | |
| SCHEMBL2726292 | 0.75 | DYRK1A (1.00) | DYRK1ACLK1KIF20ATDO2MAPT | |
| SCHEMBL2726304 | 0.75 | DYRK1A (1.00) | DYRK1ACLK1KIF20ATDO2MAPT | |
| SCHEMBL2726307 | 0.75 | DYRK1A (1.00) | DYRK1ACLK1KIF20ATDO2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2445497-B1 | Use of derivatives of indoles for the treatment of cancer | CENTRE NAT DE LA RECH SCIENT (C N R S ) (FR) | 2017-08-02 | — | — | EP | claimed |
| CN-102481285-A | Use of derivatives of indole for the treatment of cancer | CENTRE NAT RECH SCIENT | 2012-05-30 | — | — | CN | claimed |
| EP-2445497-A2 | USE OF DERIVATIVES OF INDOLES FOR THE TREATMENT OF CANCER | Centre National de la Recherche Scientifique (FR) | 2012-05-02 | — | — | EP | claimed |
| WO-2010150211-A2 | USE OF DERIVATIVES OF INDOLES FOR THE TREATMENT OF CANCER | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) | 2010-12-29 | — | — | WO | claimed |
| EP-2266562-A1 | Use of derivatives of indoles for the treatment of cancer | Centre National de la Recherche Scientifique (FR) | 2010-12-29 | — | — | EP | claimed |
| CN-109863144-B | Novel indole derivatives for the treatment of endometriosis | 生物控制术公司 | 2021-12-28 | — | — | CN | disclosed |
| CN-102481285-A | Use of derivatives of indole for the treatment of cancer | CENTRE NAT RECH SCIENT | 2012-05-30 | — | — | CN | disclosed |
| EP-2445497-A2 | USE OF DERIVATIVES OF INDOLES FOR THE TREATMENT OF CANCER | Centre National de la Recherche Scientifique (FR) | 2012-05-02 | — | — | EP | disclosed |
| WO-2010150211-A2 | USE OF DERIVATIVES OF INDOLES FOR THE TREATMENT OF CANCER | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) | 2010-12-29 | — | — | WO | disclosed |