Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF20A | O95235 | 11/20 | 0.54 |
| ▸ | DYRK1A | Q13627 | 6/20 | 0.54 |
| ▸ | CLK1 | P49759 | 4/20 | 0.47 |
| ▸ | PIP4K2A | P48426 | 1/20 | 0.44 |
| ▸ | SPR | P35270 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | CLK2 | P49760 | 1/20 | 0.39 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.39 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.39 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.39 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.39 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2726861 | 1.00 | KIF20A (0.54) | KIF20ADYRK1ACLK1PIP4K2ASPR | |
| SCHEMBL2726865 | 0.84 | KIF20A (0.68) | KIF20ADYRK1ACLK1 | |
| SCHEMBL3434452 | 0.82 | DYRK1A (0.56) | KIF20ADYRK1ACLK1MEN1KMT2A | |
| SCHEMBL2726433 | 0.81 | KIF20A (0.59) | KIF20ADYRK1ACLK1PIP4K2AMEN1 | |
| SCHEMBL2726951 | 0.80 | DYRK1A (0.50) | KIF20ADYRK1ACLK1MEN1KMT2A | |
| SCHEMBL2725919 | 0.78 | DYRK1A (0.59) | KIF20ADYRK1ACLK1 | |
| SCHEMBL2725962 | 0.76 | KIF20A (0.56) | KIF20ADYRK1ACLK1MEN1KMT2A | |
| SCHEMBL2711278 | 0.76 | DYRK1A (0.78) | KIF20ADYRK1ACLK1PIP4K2AMEN1 | |
| SCHEMBL2711280 | 0.76 | DYRK1A (0.78) | KIF20ADYRK1ACLK1PIP4K2AMEN1 | |
| SCHEMBL30937474 | 0.76 | DYRK1A (0.78) | KIF20ADYRK1ACLK1PIP4K2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2445497-B1 | Use of derivatives of indoles for the treatment of cancer | CENTRE NAT DE LA RECH SCIENT (C N R S ) (FR) | 2017-08-02 | — | — | EP | claimed |
| EP-2445497-A2 | USE OF DERIVATIVES OF INDOLES FOR THE TREATMENT OF CANCER | Centre National de la Recherche Scientifique (FR) | 2012-05-02 | — | — | EP | claimed |
| WO-2010150211-A2 | USE OF DERIVATIVES OF INDOLES FOR THE TREATMENT OF CANCER | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) | 2010-12-29 | — | — | WO | claimed |
| EP-2266562-A1 | Use of derivatives of indoles for the treatment of cancer | Centre National de la Recherche Scientifique (FR) | 2010-12-29 | — | — | EP | claimed |