Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 2/20 | 0.42 |
| ▸ | NR1H2 | P55055 | 3/20 | 0.42 |
| ▸ | NR1H3 | Q13133 | 3/20 | 0.42 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.41 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.41 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.41 |
| ▸ | ATR | Q13535 | 3/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.39 |
| ▸ | TAB1 | Q15750 | 1/20 | 0.39 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | SYK | P43405 | 1/20 | 0.37 |
| ▸ | RXRA | P19793 | 1/20 | 0.37 |
| ▸ | PRKDC | P78527 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27260619 | 0.89 | NR1H2 (0.41) | MTORNR1H2NR1H3ALOX5APJAK2 | |
| SCHEMBL27260990 | 0.83 | NR1H2 (0.42) | NR1H2NR1H3CYP2C9SYKRXRA | |
| SCHEMBL27260814 | 0.83 | NR1H2 (0.42) | NR1H2NR1H3CYP2C9SYKRXRA | |
| SCHEMBL27260617 | 0.82 | KCNH2 (0.47) | NR1H2NR1H3MAP3K7TAB1LOXL2 | |
| SCHEMBL722404 | 0.80 | PDE4C (0.46) | NR1H2NR1H3JAK2CA1CA2 | |
| SCHEMBL724751 | 0.80 | MAP3K7 (0.47) | NR1H2NR1H3MAP3K7TAB1LOXL2 | |
| SCHEMBL30765233 | 0.78 | MAP3K7 (0.39) | MTORNR1H2NR1H3JAK2PIK3CB | |
| SCHEMBL30765322 | 0.78 | FYN (0.41) | NR1H2NR1H3ATRMAP3K7TAB1 | |
| SCHEMBL27260622 | 0.78 | NR1H2 (0.38) | MTORNR1H2NR1H3JAK2PIK3CB | |
| SCHEMBL27260722 | 0.76 | NR1H2 (0.43) | NR1H2NR1H3JAK2SYKRXRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024033280-A1 | FUROPYRIDIN AND FUROPYRIMIDIN, INHIBITORS OF PI4K, FOR USE IN THE TREATMENT OF PARASITE INFECTION AND MALARIA | MERCK PATENT GMBH (DE) | 2024-02-15 | — | — | WO | disclosed |