Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K7 | O43318 | 1/20 | 0.39 |
| ▸ | TAB1 | Q15750 | 1/20 | 0.39 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.37 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.37 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.36 |
| ▸ | MTOR | P42345 | 1/20 | 0.36 |
| ▸ | PRKDC | P78527 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | ATR | Q13535 | 1/20 | 0.36 |
| ▸ | ATRIP | Q8WXE1 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.35 |
| ▸ | CCNC | P24863 | 2/20 | 0.35 |
| ▸ | CDK8 | P49336 | 2/20 | 0.35 |
| ▸ | SCD5 | Q86SK9 | 1/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | MET | P08581 | 2/20 | 0.34 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.34 |
| ▸ | PIM1 | P11309 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27260617 | 0.82 | KCNH2 (0.47) | MAP3K7TAB1NR1H2NR1H3BRD4 | |
| SCHEMBL724751 | 0.82 | MAP3K7 (0.47) | MAP3K7TAB1NR1H2NR1H3BRD4 | |
| SCHEMBL27260622 | 0.81 | NR1H2 (0.38) | MAP3K7TAB1NR1H2NR1H3PIK3CB | |
| SCHEMBL10268110 | 0.79 | MET (0.44) | MAP3K7TAB1CCNCCDK8MET | |
| SCHEMBL27260619 | 0.79 | NR1H2 (0.41) | MAP3K7TAB1NR1H2NR1H3PIK3CB | |
| SCHEMBL27260814 | 0.78 | NR1H2 (0.42) | NR1H2NR1H3ACVR1KCNH2SYK | |
| SCHEMBL27260990 | 0.78 | NR1H2 (0.42) | NR1H2NR1H3ACVR1KCNH2SYK | |
| SCHEMBL27260720 | 0.78 | MTOR (0.42) | MAP3K7TAB1NR1H2NR1H3PIK3CB | |
| SCHEMBL27260722 | 0.76 | NR1H2 (0.43) | NR1H2NR1H3BRD4KCNH2JAK2 | |
| SCHEMBL30765332 | 0.76 | KCNH2 (0.42) | MAP3K7TAB1NR1H2NR1H3PIK3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024033280-A1 | FUROPYRIDIN AND FUROPYRIMIDIN, INHIBITORS OF PI4K, FOR USE IN THE TREATMENT OF PARASITE INFECTION AND MALARIA | MERCK PATENT GMBH (DE) | 2024-02-15 | — | — | WO | disclosed |