Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FYN | P06241 | 2/20 | 0.41 |
| ▸ | ACVR1B | P36896 | 1/20 | 0.38 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.38 |
| ▸ | TDO2 | P48775 | 1/20 | 0.36 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.36 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.36 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.36 |
| ▸ | MELK | Q14680 | 2/20 | 0.36 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.35 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.35 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 3/20 | 0.35 |
| ▸ | ATR | Q13535 | 1/20 | 0.35 |
| ▸ | PAICS | P22234 | 1/20 | 0.34 |
| ▸ | OXTR | P30559 | 1/20 | 0.34 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.34 |
| ▸ | TAB1 | Q15750 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27260619 | 0.80 | NR1H2 (0.41) | ACVR1NR1H2NR1H3RIPK2NOD2 | |
| SCHEMBL27260720 | 0.78 | MTOR (0.42) | NR1H2NR1H3RIPK2NOD2ATM | |
| SCHEMBL27260814 | 0.76 | NR1H2 (0.42) | ACVR1NR1H2NR1H3KCNH2 | |
| SCHEMBL27260990 | 0.76 | NR1H2 (0.42) | ACVR1NR1H2NR1H3KCNH2 | |
| SCHEMBL30765233 | 0.74 | MAP3K7 (0.39) | ACVR1NR1H2NR1H3ATMATR | |
| SCHEMBL722404 | 0.74 | PDE4C (0.46) | FYNNR1H2NR1H3 | |
| SCHEMBL27260617 | 0.74 | KCNH2 (0.47) | ACVR1NR1H2NR1H3MAP3K7TAB1 | |
| SCHEMBL724751 | 0.72 | MAP3K7 (0.47) | ACVR1NR1H2NR1H3MAP3K7TAB1 | |
| SCHEMBL30765376 | 0.72 | MAP3K7 (0.39) | ACVR1NR1H2NR1H3ATMATR | |
| SCHEMBL27260978 | 0.72 | MAP3K7 (0.39) | ACVR1NR1H2NR1H3ATMATR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024033280-A1 | FUROPYRIDIN AND FUROPYRIMIDIN, INHIBITORS OF PI4K, FOR USE IN THE TREATMENT OF PARASITE INFECTION AND MALARIA | MERCK PATENT GMBH (DE) | 2024-02-15 | — | — | WO | disclosed |