Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | CNR2 | P34972 | 1/20 | 0.40 |
| ▸ | CRHR1 | P34998 | 2/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | JAK3 | P52333 | 1/20 | 0.39 |
| ▸ | ESR1 | P03372 | 1/20 | 0.38 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.38 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.37 |
| ▸ | PDE4A | P27815 | 1/20 | 0.37 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.37 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20844355 | 0.77 | MAPT (0.63) | SMN1; SMN2TSHRMAPTCNR2CRHR1 | |
| SCHEMBL2726149 | 0.77 | DHFR (0.53) | SMN1; SMN2TSHRKDM4EKMT2APDPK1 | |
| SCHEMBL6265329 | 0.73 | SMN1; SMN2 (0.73) | SMN1; SMN2KDM4EKMT2AHRH4 | |
| SCHEMBL1367936 | 0.73 | TSHR (0.51) | SMN1; SMN2TSHRKDM4EMAPTCNR2 | |
| SCHEMBL11930807 | 0.69 | KCNN3 (0.41) | SMN1; SMN2TSHRPDPK1CNR2CRHR1 | |
| SCHEMBL5134194 | 0.69 | TSHR (0.50) | SMN1; SMN2TSHRKDM4EKMT2APDPK1 | |
| SCHEMBL11292840 | 0.68 | MAPT (0.50) | SMN1; SMN2TSHRMAPTJAK2 | |
| SCHEMBL2724055 | 0.66 | PDPK1 (0.43) | SMN1; SMN2KDM4EPDPK1MAPTJAK2 | |
| SCHEMBL2724430 | 0.66 | PDPK1 (0.43) | SMN1; SMN2TSHRKDM4EKMT2APDPK1 | |
| SCHEMBL12609970 | 0.66 | TSHR (0.64) | SMN1; SMN2TSHRKDM4EKMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9238651-B2 | 1-H-pyrrolo[2,3-b]pyridine derivatives | MERCK PATENT GMBH (DE) | 2016-01-19 | — | — | US | disclosed |
| CN-103180320-B | 1H-pyrrolo [2,3-b ] pyridine derivatives | MERCK PATENT GMBH (DE) | 2015-10-07 | — | — | CN | disclosed |
| US-20140371215-A1 | 1-H-Pyrrolo[2,3-b]Pyridine Derivatives | MERCK PATENT GMBH (DE) | 2014-12-18 | — | — | US | disclosed |
| US-8895575-B2 | 1 H-pyrrolo[2,3-b]pyridine derivatives | MERCK PATENT GMBH (DE) | 2014-11-25 | — | — | US | disclosed |
| EP-2635574-B1 | 1H-PYRROLO[2,3-B]PYRIDINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2014-09-10 | — | — | EP | disclosed |
| US-20140100221-A1 | 1H-Pyrrolo[2,3-b]Pyridine Derivatives | MERCK PATENT GMBH (DE) | 2014-04-10 | — | — | US | disclosed |
| US-8664236-B2 | 1H-pyrrolo[2,3 b]-pyridine derivatives | MERCK PATENT GMBH (DE) | 2014-03-04 | — | — | US | disclosed |
| EP-2635574-A1 | 1H-PYRROLO[2,3-B]PYRIDINE DERIVATIVES | Merck Patent GmbH (DE) | 2013-09-11 | — | — | EP | disclosed |
| US-20130231519-A1 | 1H-Pyrrolo[2,3 b]pyridine derivatives | MERCK PATENT GMBH (DE) | 2013-09-05 | — | — | US | disclosed |
| CN-103180320-A | 1H-pyrrolo [2,3-b ] pyridine derivatives | MERCK PATENT GMBH | 2013-06-26 | — | — | CN | disclosed |
| WO-2012059172-A1 | 1H-PYRROLO[2,3-B]PYRIDINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2012-05-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140371215-A1 | 1-H-Pyrrolo[2,3-b]Pyridine Derivatives | MKI67, CDK4, CCNH | SMN1; SMN2 1513/4885TSHR 2927/4885KDM4E 1531/4885 |
| US-20130231519-A1 | 1H-Pyrrolo[2,3 b]pyridine derivatives | MKI67, CDK4, TP53 | SMN1; SMN2 1360/4885TSHR 2691/4885KDM4E 1246/4885 |
| US-20140100221-A1 | 1H-Pyrrolo[2,3-b]Pyridine Derivatives | MKI67, CDK4, TP53 | SMN1; SMN2 1259/4885TSHR 2564/4885KDM4E 1335/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.