Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPX4 | P36969 | 8/20 | 0.61 |
| ▸ | NPC1 | O15118 | 5/20 | 0.49 |
| ▸ | RAB9A | P51151 | 5/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | YAP1 | P46937 | 1/20 | 0.49 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.49 |
| ▸ | TEAD4 | Q15561 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27264417 | 0.87 | GPX4 (0.71) | GPX4NPC1RAB9ASMN1; SMN2LMNA | |
| SCHEMBL27264595 | 0.86 | GPX4 (0.68) | GPX4NPC1RAB9ASMN1; SMN2LMNA | |
| SCHEMBL27264426 | 0.83 | GPX4 (0.67) | GPX4NPC1RAB9ASMN1; SMN2LMNA | |
| SCHEMBL27264422 | 0.83 | GPX4 (0.66) | GPX4NPC1RAB9ASMN1; SMN2LMNA | |
| SCHEMBL27264728 | 0.82 | GPX4 (0.70) | GPX4NPC1RAB9ASMN1; SMN2LMNA | |
| SCHEMBL27264423 | 0.82 | GPX4 (0.72) | GPX4NPC1RAB9ASMN1; SMN2LMNA | |
| SCHEMBL27264592 | 0.81 | GPX4 (0.64) | GPX4NPC1RAB9ASMN1; SMN2LMNA | |
| SCHEMBL27264826 | 0.81 | GPX4 (0.71) | GPX4NPC1RAB9ASMN1; SMN2LMNA | |
| SCHEMBL27264598 | 0.81 | GPX4 (0.74) | GPX4NPC1RAB9ASMN1; SMN2LMNA | |
| SCHEMBL27264823 | 0.80 | GPX4 (0.63) | GPX4NPC1RAB9ASMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024030651-A1 | GPX4 INHIBITORS AND USE THEREOF | SONATA THERAPEUTICS, INC. (US) | 2024-02-08 | — | — | WO | disclosed |