Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPX4 | P36969 | 8/20 | 0.70 |
| ▸ | NPC1 | O15118 | 2/20 | 0.58 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.58 |
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
| ▸ | MAPT | P10636 | 1/20 | 0.58 |
| ▸ | YAP1 | P46937 | 1/20 | 0.58 |
| ▸ | RAB9A | P51151 | 1/20 | 0.58 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.58 |
| ▸ | TEAD4 | Q15561 | 1/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.58 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | C5AR1 | P21730 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14788390 | 0.89 | GPX4 (0.54) | GPX4NPC1NPSR1LMNAMAPT | |
| SCHEMBL27264584 | 0.87 | GPX4 (0.75) | GPX4NPC1NPSR1LMNAMAPT | |
| SCHEMBL27264585 | 0.86 | GPX4 (0.74) | GPX4NPC1NPSR1LMNAMAPT | |
| SCHEMBL27264598 | 0.86 | GPX4 (0.74) | GPX4NPC1NPSR1LMNAMAPT | |
| SCHEMBL29864762 | 0.84 | GPX4 (0.49) | GPX4NPC1NPSR1LMNAMAPT | |
| SCHEMBL14788388 | 0.84 | GPX4 (0.49) | GPX4NPC1NPSR1LMNAMAPT | |
| SCHEMBL27262545 | 0.82 | GPX4 (1.00) | GPX4NPC1NPSR1LMNAMAPT | |
| SCHEMBL27264725 | 0.82 | GPX4 (0.61) | GPX4NPC1NPSR1LMNAMAPT | |
| SCHEMBL27264426 | 0.81 | GPX4 (0.67) | GPX4NPC1NPSR1LMNAMAPT | |
| SCHEMBL27264417 | 0.81 | GPX4 (0.71) | GPX4NPC1NPSR1LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024030651-A1 | GPX4 INHIBITORS AND USE THEREOF | SONATA THERAPEUTICS, INC. (US) | 2024-02-08 | — | — | WO | disclosed |