SCHEMBL2726486

SCHEMBL2726486

COc1c(F)c(F)c(-c2c3ccccc3c(-c3ccccc3)c3c(F)c(F)c(F)c(F)c23)c(F)c1F

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PDE4B Q07343 6/20 0.41
PDE4A P27815 5/20 0.41
PDE4C Q08493 5/20 0.41
PDE4D Q08499 5/20 0.41
ALDH1A1 P00352 2/20 0.38
KDM4E B2RXH2 1/20 0.38
MAPK1 P28482 1/20 0.38
SMN1; SMN2 Q16637 1/20 0.38
ALOX5AP P20292 1/20 0.36
FEN1 P39748 1/20 0.36
POLB P06746 1/20 0.36
ABCG2 Q9UNQ0 2/20 0.35
ACHE P22303 3/20 0.33
HSD17B10 Q99714 1/20 0.33
CYP2C9 P11712 1/20 0.32
CYP3A4 P08684 1/20 0.32
TUBB4A P04350 3/20 0.32
TUBB P07437 3/20 0.32
TUBA3C P0DPH7 3/20 0.32
TUBA1B P68363 3/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2934840 0.92 ALDH1A1 (0.45) PDE4BPDE4APDE4CPDE4DALDH1A1
SCHEMBL2724358 0.92 ALDH1A1 (0.45) PDE4BPDE4APDE4CPDE4DALDH1A1
SCHEMBL2727154 0.90 ACHE (0.43) ALDH1A1KDM4EMAPK1SMN1; SMN2ABCG2
SCHEMBL2727365 0.89 PDE4B (0.40) PDE4BPDE4APDE4CPDE4DALDH1A1
SCHEMBL2727508 0.89 DHODH (0.39) PDE4BPDE4APDE4CPDE4DALDH1A1
SCHEMBL2724745 0.89 PDE4B (0.44) PDE4BPDE4APDE4CPDE4DALDH1A1
SCHEMBL2728503 0.87 CYP1A2 (0.40) PDE4BPDE4APDE4CPDE4DALDH1A1
SCHEMBL2712283 0.87 PDE4B (0.46) PDE4BPDE4APDE4CPDE4DALDH1A1
SCHEMBL2726648 0.87 KDM4E (0.35) ALDH1A1KDM4EMAPK1SMN1; SMN2POLB
SCHEMBL2725457 0.87 ACHE (0.36) ALDH1A1KDM4EMAPK1POLBACHE

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2445987-B1 BLUE/VIOLET DIPHENYLANTHRACENE CHEMILUMINESCENT FLUORESCERS CYALUME TECH INC (US) 2018-05-02 EP disclosed
EP-2445987-B1 BLUE/VIOLET DIPHENYLANTHRACENE CHEMILUMINESCENT FLUORESCERS CYALUME TECH INC (US) 2018-05-02 EP disclosed
US-8257620-B2 Blue/violet diphenylanthracene chemiluminescent fluorescers CYALUME TECHNOLOGIES, INC. (US) 2012-09-04 US disclosed
US-8257620-B2 Blue/violet diphenylanthracene chemiluminescent fluorescers CYALUME TECHNOLOGIES, INC. (US) 2012-09-04 US disclosed
EP-2445987-A1 BLUE/VIOLET DIPHENYLANTHRACENE CHEMILUMINESCENT FLUORESCERS Cyalume Technologies, Inc (US) 2012-05-02 EP disclosed
US-20100327240-A1 Blue/violet diphenylanthracene chemiluminescent fluorescers CYALUME TECHNOLOGIES, INC. 2010-12-30 US disclosed
US-20100327240-A1 Blue/violet diphenylanthracene chemiluminescent fluorescers CYALUME TECHNOLOGIES, INC. 2010-12-30 US disclosed
WO-2010151654-A1 BLUE/VIOLET DIPHENYLANTHRACENE CHEMILUMINESCENT FLUORESCERS CYALUME TECHNOLOGIES, INC. (US) 2010-12-29 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100327240-A1 Blue/violet diphenylanthracene chemiluminescent fluorescers CYP2F1, FLAD1, AFF1 PDE4B 761/4885PDE4A 831/4885PDE4C 826/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.