Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.38 |
| ▸ | FAAH | O00519 | 2/20 | 0.36 |
| ▸ | CES2 | O00748 | 1/20 | 0.36 |
| ▸ | CES1 | P23141 | 1/20 | 0.36 |
| ▸ | CNR1 | P21554 | 2/20 | 0.36 |
| ▸ | CNR2 | P34972 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21423056 | 0.76 | MC4R (0.37) | CES2CES1 | |
| SCHEMBL19405286 | 0.76 | MC4R (0.37) | CES2CES1 | |
| SCHEMBL3914165 | 0.74 | CES2 (0.44) | FAAHCES2CES1LMNAPKM | |
| SCHEMBL27265516 | 0.73 | FAAH (0.39) | FAAHCES2CES1CNR1CNR2 | |
| SCHEMBL22664585 | 0.71 | NR1I2 (0.40) | FAAHCES2CES1PKM | |
| SCHEMBL8364782 | 0.70 | CNR2 (0.37) | CNR2LMNAHPGDHDAC3HDAC1 | |
| SCHEMBL11079923 | 0.69 | CES2 (0.47) | CES2CES1PKM | |
| SCHEMBL16442483 | 0.69 | MC4R (0.38) | FAAHCES2CES1PKM | |
| SCHEMBL9234989 | 0.69 | MC4R (0.38) | FAAHCES2CES1PKM | |
| SCHEMBL20226515 | 0.68 | ESR2 (0.32) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1021819-C | PROCESS FOR DIUREA DERIVATIVES USEFUL AS MEDICAMENTS | YAMANOUCHI PHARMA CO LTD (JP) | 1993-08-18 | — | — | CN | disclosed |
| CN-1034538-A | As useful diurea derivatives of medicine and preparation method thereof | YAMANOUCHI PHARMA CO LTD (JP) | 1989-08-09 | — | — | CN | disclosed |