SCHEMBL27267482

SCHEMBL27267482

COc1cccc(Pc2ccncc2)c1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A1 P04798 2/20 0.46
CYP1A2 P05177 2/20 0.46
CYP1B1 Q16678 2/20 0.46
CYP2D6 P10635 1/20 0.46
ALDH1A1 P00352 2/20 0.45
NPC1 O15118 2/20 0.43
RAB9A P51151 2/20 0.43
DYRK1A Q13627 1/20 0.43
CLK4 Q9HAZ1 1/20 0.43
ACHE P22303 1/20 0.42
NFE2L2 Q16236 1/20 0.42
LMNA P02545 3/20 0.42
MAPT P10636 2/20 0.42
KDM4E B2RXH2 1/20 0.42
MAPK1 P28482 1/20 0.42
KMT2A Q03164 2/20 0.41
MEN1 O00255 1/20 0.41
CA1 P00915 1/20 0.41
CA2 P00918 1/20 0.41
CA7 P43166 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8029394 0.87 ACHE (0.54) CYP1A2ALDH1A1NPC1RAB9ADYRK1A
SCHEMBL18575649 0.85 CA4 (0.52) CYP1A2ALDH1A1NPC1RAB9AACHE
Hydrochloric Acid SCHEMBL28248413 0.85 ACHE (0.52) ALDH1A1NPC1RAB9ADYRK1ACLK4
Hydrochloric Acid SCHEMBL2154395 0.85 ACHE (0.52) ALDH1A1NPC1RAB9ADYRK1ACLK4
Hydrochloric Acid SCHEMBL2155238 0.83 CA4 (0.50) CYP1A2ALDH1A1NPC1RAB9AACHE
SCHEMBL27265881 0.83 CYP1A2 (0.47) CYP1A1CYP1A2CYP1B1CYP2D6ALDH1A1
SCHEMBL27268769 0.79 CYP1A2 (0.53) CYP1A1CYP1A2CYP1B1CYP2D6ALDH1A1
SCHEMBL27268061 0.79 CLK4 (0.51) ALDH1A1NPC1RAB9ADYRK1ACLK4
SCHEMBL27269274 0.75 DYRK1A (0.47) ALDH1A1NPC1RAB9ADYRK1ACLK4
SCHEMBL27702748 0.75 ALDH1A1 (0.52) ALDH1A1NPC1RAB9AACHENFE2L2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-1019193-B Process for carbonylation of ethylenically unsaturated compounds with palladium catalyst SHELL INT RESEARCH (NL) 1992-11-25 CN disclosed
CN-88101206-A The method of the carbonylation of ethylenically unsaturated compounds under palladium catalyst 1988-09-28 CN disclosed