Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A3 known ✓ | Q01959 | 1/20 | 0.44 |
| ▸ | SIGMAR1 known ✓ | Q99720 | 2/20 | 0.43 |
| ▸ | HTR1A known ✓ | P08908 | 1/20 | 0.40 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.43 |
| ▸ | RELA | Q04206 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | INMT | O95050 | 3/20 | 0.42 |
| ▸ | CHRNA1 | P02708 | 1/20 | 0.42 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.42 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL9512786 | 0.83 | CHRNA1 (0.59) | SIGMAR1KDM4ENPC1LMNAMAPT | |
| SCHEMBL25002012 | 0.81 | CHRNA1 (0.60) | SIGMAR1CYP2D6KDM4ENPC1LMNA | |
| SCHEMBL10441288 | 0.78 | TAAR1 (0.60) | SLC6A3TAAR1SIGMAR1CYP1A2CYP2D6 | |
| Hydrochloric Acid SCHEMBL11726570 | 0.75 | HRH3 (0.50) | TAAR1KDM4ENPC1LMNAMAPT | |
| SCHEMBL25002904 | 0.71 | INMT (0.51) | SIGMAR1CYP2D6LMNASMN1; SMN2INMT | |
| SCHEMBL25001916 | 0.70 | CHRNA1 (0.49) | SIGMAR1CYP2D6KDM4ELMNAMAPT | |
| SCHEMBL7735363 | 0.69 | — | — | |
| Hydrochloric Acid SCHEMBL11725366 | 0.68 | CHRNA1 (0.36) | KDM4ENPC1LMNAMAPTNFKB1 | |
| Hydrochloric Acid SCHEMBL11721131 | 0.68 | INMT (0.36) | KDM4ENPC1LMNAMAPTNFKB1 | |
| Bromide SCHEMBL8674805 | 0.68 | INMT (0.48) | KDM4ENPC1LMNAMAPTNFKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1019196-B | Process for preparing 2-thiazolidinone derivatives | RICHTER GEDEON VEGYESZET (HU) | 1992-11-25 | — | — | CN | disclosed |
| CN-1033625-A | 2-thiazolidinone derivatives, pharmaceutical compositions containing the same, and process for producing the same | RICHTER GEDEON VEGYESZET (HU) | 1989-07-05 | — | — | CN | disclosed |