Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 known ✓ | Q99720 | 1/20 | 0.44 |
| ▸ | CHRNA1 | P02708 | 1/20 | 0.59 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.44 |
| ▸ | RELA | Q04206 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | INMT | O95050 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25002012 | 0.98 | CHRNA1 (0.60) | CHRNA1CHRNA7MAPK1LMNAKDM4E | |
| SCHEMBL25002904 | 0.88 | INMT (0.51) | CHRNA1CHRNA7MAPK1LMNASMN1; SMN2 | |
| SCHEMBL25001916 | 0.86 | CHRNA1 (0.49) | CHRNA1CHRNA7MAPK1LMNAKDM4E | |
| Bromide SCHEMBL27273151 | 0.83 | SLC6A3 (0.44) | CHRNA1CHRNA7LMNAKDM4EMAPT | |
| SCHEMBL7507814 | 0.82 | CHRNA7 (0.68) | CHRNA1CHRNA7LMNAKDM4EMAPT | |
| SCHEMBL7999126 | 0.81 | CHRNA7 (0.61) | CHRNA1CHRNA7MAPK1LMNAKDM4E | |
| SCHEMBL4182979 | 0.80 | MAPK1 (0.57) | MAPK1LMNAKDM4EMAPTSMN1; SMN2 | |
| SCHEMBL6359826 | 0.79 | CHRNA1 (0.59) | CHRNA1CHRNA7MAPK1LMNAKDM4E | |
| SCHEMBL10416940 | 0.76 | KMT2A (0.58) | MAPK1LMNAKDM4EMAPTSMN1; SMN2 | |
| Descyanothiacloprid SCHEMBL1556829 | 0.74 | CHRNA7 (1.00) | CHRNA1CHRNA7SMN1; SMN2TDP1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0320910-B1 | 2-Thiazolidinone derivatives, pharmaceutical compositions containing them, process for preparing same, and use | RICHTER GEDEON VEGYESZET (HU) | 1993-12-08 | — | — | EP | disclosed |
| US-4937252-A | 2-thiazolidinone derivatives, pharmaceutical compositions containing them and process for preparing same | RICHTER GEDEON VEGYESZETI GYAR RT. (HU) | 1990-06-26 | — | — | US | disclosed |
| EP-0320910-A1 | 2-Thiazolidinone derivatives, pharmaceutical compositions containing them, process for preparing same, and use | RICHTER GEDEON VEGYESZETI GYAR R.T. (HU) | 1989-06-21 | — | — | EP | disclosed |
| US-4616025-A | ANTIULCER AGENTS | RICHTER GEDEON VEGYESZETI GYAR RT (HU) | 1986-10-07 | — | — | US | disclosed |