Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 4/20 | 0.43 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.42 |
| ▸ | SYK | P43405 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | AR | P10275 | 4/20 | 0.38 |
| ▸ | NAMPT | P43490 | 1/20 | 0.37 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27362417 | 0.86 | PRMT1 (0.43) | RORCPRMT1ALDH1A1MAPTNAMPT | |
| SCHEMBL30690770 | 0.85 | AR (0.42) | RORCPRMT1ALDH1A1ARCYP2C19 | |
| SCHEMBL1885546 | 0.79 | LMNA (0.58) | ALDH1A1MAPTCYP2C19 | |
| SCHEMBL29537831 | 0.79 | LMNA (0.58) | ALDH1A1MAPTCYP2C19 | |
| SCHEMBL27280382 | 0.79 | MAP4K4 (0.44) | RORCSYKARNAMPTMAP4K4 | |
| SCHEMBL30690681 | 0.79 | MAP4K4 (0.44) | RORCSYKARNAMPTMAP4K4 | |
| SCHEMBL5203871 | 0.78 | ALDH1A1 (0.45) | PRMT1ALDH1A1MAPT | |
| SCHEMBL29995208 | 0.77 | PRMT1 (0.40) | RORCPRMT1SYKALDH1A1MAPT | |
| SCHEMBL2134731 | 0.76 | SMN1; SMN2 (0.45) | ALDH1A1MAPTAR | |
| SCHEMBL30896778 | 0.76 | AR (0.48) | PRMT1ALDH1A1MAPTARCYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023247595-A1 | PYRAZOLOPYRAZINE CARBOXAMIDES AND THEIR USES AS PDGFR INHIBITORS | ACTELION PHARMACEUTICALS LTD (CH) | 2023-12-28 | — | — | WO | disclosed |
| WO-2023247593-A1 | PYRROLOPYRIDINE CARBOXAMIDES AND THEIR USES AS PDGFR INHIBITORS | ACTELION PHARMACEUTICALS LTD (CH) | 2023-12-28 | — | — | WO | disclosed |
| WO-2023247593-A1 | PYRROLOPYRIDINE CARBOXAMIDES AND THEIR USES AS PDGFR INHIBITORS | ACTELION PHARMACEUTICALS LTD (CH) | 2023-12-28 | — | — | WO | disclosed |