Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4B | O94953 | 2/20 | 0.39 |
| ▸ | KDM5C | P41229 | 2/20 | 0.39 |
| ▸ | KDM5B | Q9UGL1 | 2/20 | 0.39 |
| ▸ | KDM4A | O75164 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 5/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.35 |
| ▸ | NPC1 | O15118 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.34 |
| ▸ | KLF5 | Q13887 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.34 |
| ▸ | GLRA3 | O75311 | 1/20 | 0.34 |
| ▸ | GLRB | P48167 | 1/20 | 0.34 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.33 |
| ▸ | STAT1 | P42224 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2728043 | 0.87 | KDM4B (0.39) | KDM4BKDM5CKDM5BKDM4ARAB9A | |
| SCHEMBL2726257 | 0.82 | PIK3CB (0.36) | RAB9ANPC1SMN1; SMN2HPGDPIK3CB | |
| SCHEMBL2724726 | 0.82 | PARP1 (0.39) | POLBPIK3CBGLRA3GLRBMAP4K1 | |
| SCHEMBL2725903 | 0.78 | PIK3CB (0.36) | PIK3CBGLRA3GLRBTGFBR1MAP4K1 | |
| SCHEMBL3347772 | 0.75 | GLRA3 (0.44) | KDM4EPIK3CBGLRA3GLRBIL2 | |
| SCHEMBL2726265 | 0.74 | TGFBR1 (0.38) | RAB9ANPC1SMN1; SMN2HPGDPIK3CB | |
| SCHEMBL2726893 | 0.73 | ADORA2A (0.36) | RAB9AKDM4EMAPTPOLBGAA | |
| SCHEMBL15600919 | 0.72 | KDM4A (0.43) | KDM4BKDM5CKDM5BKDM4ARAB9A | |
| SCHEMBL10320333 | 0.72 | BRD4 (0.46) | SMN1; SMN2PIK3CBGLRA3GLRBIL2 | |
| SCHEMBL3648919 | 0.71 | PIK3CB (0.36) | RAB9ANPC1SMN1; SMN2HPGDPIK3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012054510-A1 | OXADIAZOLE COMPOUNDS WHICH INHIBIT BETA-SECRETASE ACTIVITY AND METHODS OF USE THEREOF | COMENTIS, INC. (US) | 2012-04-26 | — | — | WO | disclosed |