Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.54 |
| ▸ | HPSE | Q9Y251 | 1/20 | 0.50 |
| ▸ | TPMT | P51580 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | CASP6 | P55212 | 1/20 | 0.46 |
| ▸ | HCAR3 | P49019 | 2/20 | 0.44 |
| ▸ | TTR | P02766 | 1/20 | 0.44 |
| ▸ | ALB | P02768 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | CA12 | O43570 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | CA9 | Q16790 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11542097 | 0.90 | HPSE (0.56) | LMNAHPSETPMTKDM4EMEN1 | |
| SCHEMBL11546125 | 0.87 | POLB (0.55) | LMNAHPSETPMTMAPK1MEN1 | |
| SCHEMBL28070439 | 0.84 | MEN1 (0.59) | LMNAHPSETPMTKDM4EMEN1 | |
| SCHEMBL14879865 | 0.83 | MAPT (0.50) | LMNAHPSETPMTKDM4EMEN1 | |
| SCHEMBL573640 | 0.82 | KDM4E (0.58) | LMNAHPSETPMTKDM4EMEN1 | |
| SCHEMBL29155879 | 0.81 | HPSE (0.48) | LMNAHPSETPMTKDM4EMEN1 | |
| SCHEMBL14879694 | 0.80 | HPSE (0.47) | LMNAHPSETPMTKDM4EMEN1 | |
| SCHEMBL14879785 | 0.79 | VCAM1 (0.51) | LMNAHPSETPMTKDM4EMEN1 | |
| SCHEMBL29192369 | 0.79 | HPSE (0.46) | LMNAHPSETPMTKDM4EMEN1 | |
| SCHEMBL16577860 | 0.78 | HPSE (0.46) | LMNAHPSETPMTKDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1011779-B | Synthesis method of diuretic butylated URAMINE | GUILIN PHARMACEUTICAL FACTORY (CN) | 1991-02-27 | — | — | CN | claimed |
| CN-86108913-A | The synthetic method of diuretic bumetanide | — | 1988-02-03 | — | — | CN | claimed |
| CN-1011779-B | Synthesis method of diuretic butylated URAMINE | GUILIN PHARMACEUTICAL FACTORY (CN) | 1991-02-27 | — | — | CN | disclosed |
| CN-86108913-A | The synthetic method of diuretic bumetanide | — | 1988-02-03 | — | — | CN | disclosed |