Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF20A | O95235 | 3/20 | 0.56 |
| ▸ | MEN1 | O00255 | 5/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.49 |
| ▸ | NPC1 | O15118 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | TUBB1 | Q9H4B7 | 1/20 | 0.42 |
| ▸ | IGF1R | P08069 | 2/20 | 0.42 |
| ▸ | MET | P08581 | 2/20 | 0.42 |
| ▸ | IDO1 | P14902 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.40 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.40 |
| ▸ | GABRP | O00591 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2725902 | 0.87 | KIF20A (0.58) | KIF20AMEN1KMT2ANPC1SMN1; SMN2 | |
| SCHEMBL2726053 | 0.77 | MEN1 (0.46) | KIF20AMEN1KMT2ANPC1SMN1; SMN2 | |
| SCHEMBL2725962 | 0.77 | KIF20A (0.56) | KIF20AMEN1KMT2ANPC1SMN1; SMN2 | |
| SCHEMBL2727891 | 0.75 | MEN1 (0.48) | KIF20AMEN1KMT2ANPC1SMN1; SMN2 | |
| SCHEMBL2725570 | 0.74 | KIF20A (0.43) | KIF20AMEN1KMT2ANPC1SMN1; SMN2 | |
| SCHEMBL2727478 | 0.74 | KIF20A (0.44) | KIF20AMEN1KMT2ANPC1SMN1; SMN2 | |
| SCHEMBL2724561 | 0.72 | KIF20A (1.00) | KIF20AMEN1KMT2ANPC1SMN1; SMN2 | |
| SCHEMBL2724567 | 0.72 | KIF20A (1.00) | KIF20AMEN1KMT2ANPC1SMN1; SMN2 | |
| SCHEMBL2726433 | 0.72 | KIF20A (0.59) | KIF20AMEN1KMT2ANPC1SMN1; SMN2 | |
| SCHEMBL2724741 | 0.72 | GABRP (0.48) | KIF20AMEN1KMT2ANPC1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2445497-B1 | Use of derivatives of indoles for the treatment of cancer | CENTRE NAT DE LA RECH SCIENT (C N R S ) (FR) | 2017-08-02 | — | — | EP | claimed |
| EP-2445497-A2 | USE OF DERIVATIVES OF INDOLES FOR THE TREATMENT OF CANCER | Centre National de la Recherche Scientifique (FR) | 2012-05-02 | — | — | EP | claimed |
| WO-2010150211-A2 | USE OF DERIVATIVES OF INDOLES FOR THE TREATMENT OF CANCER | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) | 2010-12-29 | — | — | WO | claimed |
| EP-2266562-A1 | Use of derivatives of indoles for the treatment of cancer | Centre National de la Recherche Scientifique (FR) | 2010-12-29 | — | — | EP | claimed |