⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30434601 | 0.78 | — | — | |
| SCHEMBL693912 | 0.57 | — | — | |
| SCHEMBL6206936 | 0.57 | — | — | |
| SCHEMBL17303466 | 0.55 | — | — | |
| SCHEMBL692808 | 0.55 | — | — | |
| SCHEMBL651902 | 0.48 | ALDH1A1 (0.71) | — | |
| SCHEMBL31397047 | 0.48 | TRPV4 (0.39) | — | |
| SCHEMBL3128058 | 0.46 | — | — | |
| SCHEMBL4432240 | 0.46 | — | — | |
| SCHEMBL82 | 0.46 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025007873-A1 | KAT6 INHIBITOR | 上海齐鲁制药研究中心有限公司 | 2025-01-09 | — | — | WO | disclosed |
| CN-117304205-A | Benzimidazole ternary fused ring compound, pharmaceutically acceptable salt thereof and application thereof | 中国科学院广州生物医药与健康研究院 | 2023-12-29 | — | — | CN | disclosed |
| EP-3890715-A1 | THERAPEUTICS TARGETING MUTANT ADENOMATOUS POLYPOSIS COLI (APC) FOR THE TREATMENT OF CANCER | The Board Of Regents Of The University Of Texas System (US) | 2021-10-13 | — | — | EP | disclosed |
| WO-2020117972-A1 | THERAPEUTICS TARGETING MUTANT ADENOMATOUS POLYPOSIS COLI (APC) FOR THE TREATMENT OF CANCER | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) | 2020-06-11 | — | — | WO | disclosed |
| CN-105801464-B | Pyrrole amides class compound and preparation method thereof and purposes | 成都先导药物开发有限公司 | 2019-05-28 | — | — | CN | disclosed |
| CN-105732597-B | A kind of midbody compound and the preparation method and application thereof preparing pyrrole amides class compound | 成都先导药物开发有限公司 | 2019-01-01 | — | — | CN | disclosed |
| CN-105829305-A | NRF2 REGULATORS | 葛兰素史密斯克莱知识产权发展有限公司 | 2016-08-03 | — | — | CN | disclosed |
| CN-105801464-A | Pyrrolic amide compound and its preparation method and use | 成都先导药物开发有限公司 | 2016-07-27 | — | — | CN | disclosed |
| CN-105732597-A | Intermediate compounds for preparing pyrrole amide compounds, preparation method and applications thereof | 成都先导药物开发有限公司 | 2016-07-06 | — | — | CN | disclosed |
| EP-2632920-A1 | SULFONAMIDES FOR THE MODULATION OF PKM2 | Dynamix Pharmaceuticals Ltd. (IL) | 2013-09-04 | — | — | EP | disclosed |
| WO-2012056319-A1 | SULFONAMIDES FOR THE MODULATION OF PKM2 | DYNAMIX PHARMACEUTICALS LTD. (IL) | 2012-05-03 | — | — | WO | disclosed |