Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 6/20 | 0.50 |
| ▸ | CNR2 | P34972 | 1/20 | 0.46 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.41 |
| ▸ | CDK2 | P24941 | 2/20 | 0.41 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.41 |
| ▸ | EP300 | Q09472 | 3/20 | 0.39 |
| ▸ | DHFR | P00374 | 1/20 | 0.39 |
| ▸ | DCPS | Q96C86 | 1/20 | 0.39 |
| ▸ | KDM1A | O60341 | 1/20 | 0.38 |
| ▸ | NOS3 | P29474 | 1/20 | 0.38 |
| ▸ | NOS1 | P29475 | 1/20 | 0.38 |
| ▸ | NOS2 | P35228 | 1/20 | 0.38 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.37 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.37 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.37 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29015227 | 0.85 | MCHR1 (0.48) | MCHR1CNR2CCNA2CDK2CCNA1 | |
| SCHEMBL5338216 | 0.83 | MCHR1 (0.63) | MCHR1DHFRDCPS | |
| SCHEMBL12093578 | 0.79 | CNR2 (0.46) | CNR2CCNA2CDK2CCNA1KDM1A | |
| SCHEMBL1391480 | 0.79 | CNR2 (0.46) | MCHR1CNR2CCNA2CDK2CCNA1 | |
| SCHEMBL30350618 | 0.79 | HTR7 (0.50) | MCHR1CNR2CCNA2CDK2CCNA1 | |
| SCHEMBL24305880 | 0.79 | CNR2 (0.46) | CNR2CCNA2CDK2CCNA1EP300 | |
| SCHEMBL5280 | 0.79 | HTR7 (0.50) | MCHR1CNR2CCNA2CDK2CCNA1 | |
| SCHEMBL16333742 | 0.79 | DRD4 (0.46) | MCHR1CNR2CCNA2CDK2CCNA1 | |
| SCHEMBL14426334 | 0.79 | CNR2 (0.46) | CNR2CCNA2CDK2CCNA1KDM1A | |
| SCHEMBL17993353 | 0.78 | FFAR2 (0.40) | MCHR1NOS3NOS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012055995-A1 | TRICYCLIC COMPOUNDS AS MPGES-1 INHIBITORS | GLENMARK PHARMACEUTICALS S.A. (CH) | 2012-05-03 | — | — | WO | disclosed |