Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR1 | O14842 | 11/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | MAPT | P10636 | 2/20 | 0.55 |
| ▸ | GMNN | O75496 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.55 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.55 |
| ▸ | THPO | P40225 | 1/20 | 0.55 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.55 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.55 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.55 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.55 |
| ▸ | SLCO1B3 | Q9NPD5 | 1/20 | 0.55 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.53 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2731005 | 0.90 | FFAR1 (0.62) | FFAR1FFAR4 | |
| SCHEMBL11468595 | 0.81 | MAPT (0.65) | FFAR1SMN1; SMN2MAPTLMNATSHR | |
| SCHEMBL11229424 | 0.80 | S1PR1 (0.62) | FFAR1SMN1; SMN2ALDH1A1HDAC3MAPK1 | |
| SCHEMBL11934944 | 0.80 | FFAR1 (0.55) | FFAR1SMN1; SMN2MAPTALDH1A1LMNA | |
| SCHEMBL11239458 | 0.80 | S1PR1 (0.62) | FFAR1SMN1; SMN2ALDH1A1HDAC3MAPK1 | |
| SCHEMBL11247581 | 0.80 | S1PR1 (0.62) | FFAR1SMN1; SMN2ALDH1A1HDAC3MAPK1 | |
| SCHEMBL10412750 | 0.79 | ALDH1A1 (0.58) | FFAR1SMN1; SMN2MAPTGMNNALDH1A1 | |
| SCHEMBL2112016 | 0.79 | FFAR1 (0.57) | FFAR1SMN1; SMN2MAPTGMNNALDH1A1 | |
| SCHEMBL6208836 | 0.78 | SMN1; SMN2 (0.82) | FFAR1SMN1; SMN2MAPTGMNNALDH1A1 | |
| SCHEMBL939423 | 0.78 | FFAR1 (0.52) | FFAR1SMN1; SMN2MAPTALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0000938-B1 | MACROMOLECULAR COVALENT CONJUGATES, METHODS FOR PREPARING AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | NATIONAL RESEARCH DEVELOPMENT CORPORATION (GB) | 1984-10-17 | — | — | EP | claimed |
| WO-2012058325-A1 | COMPOUNDS AND METHODS USEFUL FOR TREATMENT OF DISEASES MEDIATED BY HIF-1 | ONCOTHYREON INC. (US) | 2012-05-03 | — | — | WO | disclosed |
| WO-2012058325-A1 | COMPOUNDS AND METHODS USEFUL FOR TREATMENT OF DISEASES MEDIATED BY HIF-1 | ONCOTHYREON INC. (US) | 2012-05-03 | — | — | WO | disclosed |
| CN-1703199-A | Aggregate with enhanced deformability comprising at least three amphiphiles for improved transport through a semi-permeable barrier and use of non-invasive drugs in vivo, in particular through the skin | IDEA AG (DE) | 2005-11-30 | — | — | CN | disclosed |
| EP-0000938-B1 | MACROMOLECULAR COVALENT CONJUGATES, METHODS FOR PREPARING AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | NATIONAL RESEARCH DEVELOPMENT CORPORATION (GB) | 1984-10-17 | — | — | EP | disclosed |