Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.55 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.53 |
| ▸ | ITGB7 | P26010 | 1/20 | 0.53 |
| ▸ | CTSS | P25774 | 5/20 | 0.50 |
| ▸ | CTSK | P43235 | 4/20 | 0.50 |
| ▸ | CTSB | P07858 | 3/20 | 0.50 |
| ▸ | CTSL | P07711 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | ACE | P12821 | 1/20 | 0.48 |
| ▸ | PPARG | P37231 | 1/20 | 0.48 |
| ▸ | PPARA | Q07869 | 1/20 | 0.48 |
| ▸ | GSTP1 | P09211 | 1/20 | 0.47 |
| ▸ | GSTM2 | P28161 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6674426 | 1.00 | KLK5 (0.55) | KLK5ITGA4ITGB7CTSSCTSK | |
| SCHEMBL4733108 | 0.92 | ITGA4 (0.50) | KLK5ITGA4ITGB7CTSSCTSK | |
| SCHEMBL3823774 | 0.92 | ITGA4 (0.50) | KLK5ITGA4ITGB7CTSSCTSK | |
| SCHEMBL16459772 | 0.91 | ITGA4 (0.49) | KLK5ITGA4ITGB7CTSSCTSK | |
| SCHEMBL16459773 | 0.91 | ITGA4 (0.49) | KLK5ITGA4ITGB7CTSSCTSK | |
| SCHEMBL2727571 | 0.91 | ACE (0.59) | KLK5ITGA4ITGB7CTSSCTSK | |
| SCHEMBL29469017 | 0.91 | ACE (0.59) | KLK5ITGA4ITGB7CTSSCTSK | |
| SCHEMBL2727573 | 0.91 | ACE (0.59) | KLK5ITGA4ITGB7CTSSCTSK | |
| SCHEMBL9956671 | 0.91 | ACE (0.59) | KLK5ITGA4ITGB7CTSSCTSK | |
| SCHEMBL9956668 | 0.91 | ACE (0.59) | KLK5ITGA4ITGB7CTSSCTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012058325-A1 | COMPOUNDS AND METHODS USEFUL FOR TREATMENT OF DISEASES MEDIATED BY HIF-1 | ONCOTHYREON INC. (US) | 2012-05-03 | — | — | WO | disclosed |