Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 4/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.50 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | P2RY1 | P47900 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | ACP1 | P24666 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.44 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.44 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.44 |
| ▸ | TMPRSS4 | Q9NRS4 | 1/20 | 0.44 |
| ▸ | FABP4 | P15090 | 1/20 | 0.44 |
| ▸ | IDO1 | P14902 | 1/20 | 0.44 |
| ▸ | GRM4 | Q14833 | 2/20 | 0.43 |
| ▸ | FADS1 | O60427 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15708595 | 0.84 | EGFR (0.66) | EGFRMEN1KMT2AMAPTNPSR1 | |
| SCHEMBL15708598 | 0.84 | EGFR (0.66) | EGFRMEN1KMT2AMAPTNPSR1 | |
| SCHEMBL4542528 | 0.80 | MEN1 (0.67) | EGFRMEN1KMT2AMAPTRAB9A | |
| SCHEMBL15893618 | 0.78 | NPC1 (0.63) | EGFRMEN1KMT2AMAPTNPSR1 | |
| SCHEMBL9354309 | 0.78 | EGFR (0.63) | EGFRMEN1KMT2AMAPTNPSR1 | |
| SCHEMBL9354315 | 0.78 | EGFR (0.63) | EGFRMEN1KMT2AMAPTNPSR1 | |
| SCHEMBL19067081 | 0.78 | EGFR (0.63) | EGFRMEN1KMT2AMAPTNPSR1 | |
| SCHEMBL733110 | 0.78 | NPSR1 (0.56) | EGFRMEN1KMT2AMAPTNPSR1 | |
| SCHEMBL733111 | 0.78 | NPSR1 (0.56) | EGFRMEN1KMT2AMAPTNPSR1 | |
| SCHEMBL19911202 | 0.77 | TGM2 (0.53) | EGFRMEN1KMT2AMAPTNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2632898-A1 | HETEROCYCLIC TYROSINE KINASE INHIBITORS | Biogen Idec MA Inc. (US) | 2013-09-04 | — | — | EP | disclosed |
| WO-2012058645-A1 | HETEROCYCLIC TYROSINE KINASE INHIBITORS | BIOGEN IDEC MA INC. (US) | 2012-05-03 | — | — | WO | disclosed |