Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.67 |
| ▸ | LMNA | P02545 | 2/20 | 0.67 |
| ▸ | MAPT | P10636 | 2/20 | 0.67 |
| ▸ | HTT | P42858 | 2/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.67 |
| ▸ | MAOB | P27338 | 5/20 | 0.62 |
| ▸ | MMP1 | P03956 | 4/20 | 0.62 |
| ▸ | MMP2 | P08253 | 4/20 | 0.62 |
| ▸ | MMP9 | P14780 | 4/20 | 0.62 |
| ▸ | MAOA | P21397 | 3/20 | 0.62 |
| ▸ | EGFR | P00533 | 1/20 | 0.62 |
| ▸ | RAB9A | P51151 | 4/20 | 0.61 |
| ▸ | NPC1 | O15118 | 3/20 | 0.61 |
| ▸ | GAA | P10253 | 1/20 | 0.55 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.54 |
| ▸ | HTR3B | O95264 | 1/20 | 0.54 |
| ▸ | HTR3A | P46098 | 1/20 | 0.54 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.54 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8472105 | 0.84 | TGM2 (0.65) | MEN1KMT2ALMNAMAPTHTT | |
| SCHEMBL22268618 | 0.81 | LPAR1 (0.77) | MEN1KMT2ALMNAMAPTHTT | |
| SCHEMBL9835434 | 0.81 | CYP1A2 (0.64) | MEN1KMT2ALMNAMAPTHTT | |
| SCHEMBL28346163 | 0.81 | CYP1A2 (0.64) | MEN1KMT2ALMNAMAPTHTT | |
| SCHEMBL505746 | 0.81 | CYP1A2 (0.64) | MEN1KMT2ALMNAMAPTHTT | |
| SCHEMBL2682054 | 0.80 | KMT2A (1.00) | MEN1KMT2ALMNAMAPTHTT | |
| SCHEMBL2728699 | 0.80 | EGFR (0.54) | MEN1KMT2ALMNAMAPTALDH1A1 | |
| SCHEMBL27582490 | 0.79 | KMT2A (0.73) | MEN1KMT2ALMNAMAPTHTT | |
| SCHEMBL2094553 | 0.79 | MEN1 (0.74) | MEN1KMT2ALMNAMAPTHTT | |
| SCHEMBL11066912 | 0.79 | MEN1 (0.74) | MEN1KMT2ALMNAMAPTHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2049520-A2 | INDOLE COMPOUNDS | Ironwood Pharmaceuticals, Inc. (US) | 2009-04-22 | — | — | EP | disclosed |
| WO-2008157740-A2 | FAAH INHIBITORS | IRONWOOD PHARMACEUTICALS, INC. (US) | 2008-12-24 | — | — | WO | disclosed |
| WO-2008019357-A2 | INDOLE COMPOUNDS | IRONWOOD PHARMACEUTICALS, INC. (US) | 2008-02-14 | — | — | WO | disclosed |