Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | ELANE | P08246 | 1/20 | 0.41 |
| ▸ | CTRB1 | P17538 | 1/20 | 0.41 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.41 |
| ▸ | IDO1 | P14902 | 1/20 | 0.40 |
| ▸ | LPAR1 | Q92633 | 3/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.38 |
| ▸ | GPR139 | Q6DWJ6 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30816959 | 1.00 | TP53 (0.44) | TP53MAPTKDM4EALDH1A1ELANE | |
| SCHEMBL2737224 | 0.83 | NLRP3 (0.56) | TP53MAPTNLRP3IDO1LPAR1 | |
| SCHEMBL32665001 | 0.81 | NPC1 (0.42) | TP53MAPTALDH1A1 | |
| SCHEMBL27289163 | 0.81 | NPC1 (0.42) | TP53MAPTALDH1A1 | |
| Hydrochloric Acid SCHEMBL32690462 | 0.80 | ALDH1A1 (0.44) | MAPTKDM4EALDH1A1LPAR1RXFP1 | |
| SCHEMBL1771858 | 0.79 | IDO1 (0.47) | TP53MAPTELANECTRB1NLRP3 | |
| Hydrochloric Acid SCHEMBL32664815 | 0.79 | ALDH1A1 (0.44) | MAPTALDH1A1RXFP1LMNA | |
| SCHEMBL17230179 | 0.78 | IDO1 (0.44) | TP53MAPTELANECTRB1NLRP3 | |
| SCHEMBL30816994 | 0.78 | KDM4E (0.38) | TP53MAPTKDM4EALDH1A1ELANE | |
| SCHEMBL30816992 | 0.78 | KDM4E (0.38) | TP53MAPTKDM4EALDH1A1ELANE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024059661-A1 | N-(BENZHYDRYL)CYCLOALKYLCARBOXAMIDE DERIVATIVES AS INHIBITORS OF GLYCOGEN SYNTHASE 1 (GYS1) AND METHODS OF USE THEREOF | MAZE THERAPEUTICS, INC. (US) | 2024-03-21 | — | — | WO | disclosed |