Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 3/20 | 0.64 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.64 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.55 |
| ▸ | KDR | P35968 | 3/20 | 0.54 |
| ▸ | FLT1 | P17948 | 2/20 | 0.54 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.54 |
| ▸ | HPGD | P15428 | 3/20 | 0.54 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.52 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.52 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.52 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.52 |
| ▸ | PDE5A | O76074 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.48 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL665733 | 0.78 | RPS6KB1 (1.00) | AURKARPS6KB1KDRAURKBHPGD | |
| SCHEMBL2728976 | 0.78 | AURKA (0.67) | AURKARPS6KB1HSD17B10KDRAURKB | |
| SCHEMBL3795994 | 0.77 | HDAC3 (0.76) | AURKARPS6KB1HSD17B10AURKBHPGD | |
| SCHEMBL12120507 | 0.76 | RPS6KB1 (0.71) | AURKARPS6KB1KDRAURKBHPGD | |
| SCHEMBL7012861 | 0.76 | RPS6KB1 (0.55) | AURKARPS6KB1HPGDKDM4EALDH1A1 | |
| SCHEMBL27847518 | 0.75 | KDM4C (0.67) | AURKARPS6KB1KDM4EALDH1A1GAA | |
| SCHEMBL25256103 | 0.75 | CDC7 (0.52) | AURKARPS6KB1AURKBKDM4EALDH1A1 | |
| SCHEMBL8300985 | 0.74 | FLT1 (0.65) | AURKAHSD17B10KDRFLT1HPGD | |
| SCHEMBL9283376 | 0.74 | KDR (0.62) | AURKARPS6KB1HSD17B10KDRHPGD | |
| SCHEMBL3714861 | 0.74 | MAPT (0.64) | AURKARPS6KB1HDAC3HDAC1HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2635556-A2 | BENZAMIDES AND NICOTINAMIDES AS SYK MODULATORS | Portola Pharmaceuticals, Inc. (US) | 2013-09-11 | — | — | EP | claimed |
| WO-2012061418-A2 | BENZAMIDES AND NICOTINAMIDES AS SYK MODULATORS | PORTOLA PHARMACEUTICALS, INC. (US) | 2012-05-10 | — | — | WO | claimed |