Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 1/20 | 0.76 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.76 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.76 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.76 |
| ▸ | PDE5A | O76074 | 2/20 | 0.61 |
| ▸ | AURKA | O14965 | 2/20 | 0.55 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.55 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.54 |
| ▸ | VNN1 | O95497 | 4/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | MMP13 | P45452 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31141723 | 0.89 | HDAC3 (0.82) | HDAC3HDAC1HDAC2HDAC6PDE5A | |
| SCHEMBL4730176 | 0.86 | HDAC1 (1.00) | HDAC3HDAC1HDAC2HDAC6VNN1 | |
| SCHEMBL31141597 | 0.82 | ALDH1A1 (0.72) | HDAC3HDAC1HDAC2HDAC6PDE5A | |
| SCHEMBL24730682 | 0.79 | VNN1 (0.53) | HDAC3HDAC1HDAC2HDAC6PDE5A | |
| SCHEMBL2728973 | 0.77 | AURKA (0.64) | HDAC3HDAC1HDAC2HDAC6PDE5A | |
| SCHEMBL7498732 | 0.76 | PDE5A (1.00) | PDE5AAURKARPS6KB1AURKBMEN1 | |
| SCHEMBL2728976 | 0.76 | AURKA (0.67) | HDAC3HDAC1HDAC2HDAC6PDE5A | |
| SCHEMBL7322125 | 0.75 | SMN1; SMN2 (0.68) | HSD17B10MEN1LMNAKMT2AMAPK1 | |
| SCHEMBL4194265 | 0.75 | AURKA (0.56) | HDAC3HDAC1HDAC2HDAC6PDE5A | |
| SCHEMBL13210625 | 0.72 | HPGD (0.69) | POLBHSD17B10MEN1LMNAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010129802-A1 | INHIBITORS OF JAK | PORTOLA PHARMACEUTICALS, INC. (US) | 2010-11-11 | — | — | WO | claimed |