Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NCF1 | P14598 | 1/20 | 0.45 |
| ▸ | ACHE | P22303 | 1/20 | 0.32 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.31 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.31 |
| ▸ | HTR1A | P08908 | 1/20 | 0.31 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.31 |
| ▸ | DRD1 | P21728 | 1/20 | 0.31 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.31 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.31 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.31 |
| ▸ | DRD3 | P35462 | 1/20 | 0.31 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27291992 | 1.00 | NCF1 (0.45) | NCF1ACHEHRH3CHRM2HTR1A | |
| SCHEMBL41970 | 0.82 | NCF1 (0.65) | NCF1ACHEHRH3CHRM2CHRM1 | |
| SCHEMBL13162611 | 0.79 | HRH3 (0.41) | NCF1HRH3CHRM2HTR1AADRA2A | |
| SCHEMBL27268812 | 0.79 | CARM1 (0.35) | NCF1HRH3 | |
| SCHEMBL27267710 | 0.79 | CARM1 (0.35) | NCF1HRH3 | |
| SCHEMBL12049732 | 0.77 | HRH3 (0.42) | NCF1HRH3CHRM2HTR1AADRA2A | |
| SCHEMBL20552382 | 0.75 | NCF1 (0.56) | NCF1ACHEHRH3CHRM2CHRM1 | |
| SCHEMBL27267776 | 0.74 | CACNA2D1 (0.37) | NCF1ACHEHRH3KCNH2 | |
| SCHEMBL27268818 | 0.74 | CACNA2D1 (0.37) | NCF1ACHEHRH3KCNH2 | |
| SCHEMBL23267643 | 0.73 | NCF1 (0.41) | NCF1HRH3CHRM2HTR1AADRA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024112692-A1 | CASITAS B-LINEAGE LYMPHOMA PROTOONCOGENE B (CBL-B) DEGRADING COMPOUNDS AND ASSOCIATED METHODS OF USE | ARVINAS OPERATIONS, INC. (US) | 2024-05-30 | — | — | WO | disclosed |