Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYK2 | P29597 | 5/20 | 0.45 |
| ▸ | JAK2 | O60674 | 4/20 | 0.45 |
| ▸ | JAK3 | P52333 | 4/20 | 0.45 |
| ▸ | JAK1 | P23458 | 3/20 | 0.45 |
| ▸ | SYK | P43405 | 7/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | MAPK9 | P45984 | 3/20 | 0.41 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.41 |
| ▸ | MAP4K1 | Q92918 | 3/20 | 0.40 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.40 |
| ▸ | CDC7 | O00311 | 1/20 | 0.40 |
| ▸ | PLK4 | O00444 | 1/20 | 0.40 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.40 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.40 |
| ▸ | CHUK | O15111 | 1/20 | 0.40 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.40 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.40 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30923183 | 1.00 | TYK2 (0.45) | TYK2JAK2JAK3JAK1SYK | |
| SCHEMBL30923307 | 0.93 | NPSR1 (0.45) | TYK2JAK2JAK3JAK1NPSR1 | |
| SCHEMBL27294096 | 0.93 | NPSR1 (0.45) | TYK2JAK2JAK3JAK1NPSR1 | |
| SCHEMBL27290901 | 0.89 | SYK (0.41) | TYK2JAK2JAK3JAK1SYK | |
| SCHEMBL27294154 | 0.89 | ALDH1A1 (0.50) | TYK2NPSR1HSD17B10PTK2IGF1R | |
| SCHEMBL27291710 | 0.89 | HSD17B10 (0.42) | TYK2JAK2JAK3JAK1SYK | |
| SCHEMBL27290762 | 0.88 | TYK2 (0.46) | TYK2JAK2JAK3JAK1SYK | |
| SCHEMBL30923195 | 0.87 | SYK (0.44) | TYK2JAK2JAK3JAK1SYK | |
| SCHEMBL27290903 | 0.87 | SYK (0.44) | TYK2JAK2JAK3JAK1SYK | |
| SCHEMBL27291804 | 0.87 | HSD17B10 (0.42) | TYK2JAK1NPSR1HSD17B10PTK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024107658-A2 | INHIBITORS OF TYK2 | VYRNWY THERAPEUTICS, INC. (US) | 2024-05-23 | — | — | WO | disclosed |