Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 16/20 | 0.44 |
| ▸ | JAK2 | O60674 | 2/20 | 0.41 |
| ▸ | BTK | Q06187 | 4/20 | 0.41 |
| ▸ | LCK | P06239 | 1/20 | 0.41 |
| ▸ | JAK3 | P52333 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2729448 | 1.00 | SYK (0.44) | SYKJAK2BTKLCKJAK3 | |
| SCHEMBL10271844 | 0.91 | SYK (0.45) | SYKJAK2BTKLCKJAK3 | |
| SCHEMBL2729181 | 0.90 | SYK (0.47) | SYK | |
| SCHEMBL2729183 | 0.90 | SYK (0.47) | SYK | |
| SCHEMBL2717554 | 0.90 | SYK (0.44) | SYK | |
| SCHEMBL2731573 | 0.90 | SYK (0.44) | SYK | |
| SCHEMBL2731588 | 0.85 | SYK (0.41) | SYK | |
| SCHEMBL2731593 | 0.85 | SYK (0.41) | SYK | |
| SCHEMBL10272220 | 0.83 | SYK (0.43) | SYK | |
| SCHEMBL2729610 | 0.83 | SYK (0.44) | SYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012061415-A1 | OXYPYRIMIDINES AS SYK MODULATORS | PORTOLA PHARMACEUTICALS, INC. (US) | 2012-05-10 | — | — | WO | disclosed |
| WO-2012061415-A1 | OXYPYRIMIDINES AS SYK MODULATORS | PORTOLA PHARMACEUTICALS, INC. (US) | 2012-05-10 | — | — | WO | disclosed |