Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 1/20 | 0.61 |
| ▸ | EGFR | P00533 | 2/20 | 0.54 |
| ▸ | GSK3B | P49841 | 3/20 | 0.54 |
| ▸ | SCN9A | Q15858 | 6/20 | 0.51 |
| ▸ | SCN5A | Q14524 | 5/20 | 0.51 |
| ▸ | PIK3CG | P48736 | 4/20 | 0.50 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.50 |
| ▸ | PIK3CB | P42338 | 3/20 | 0.50 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.50 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.50 |
| ▸ | PRKACA | P17612 | 1/20 | 0.50 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.50 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.50 |
| ▸ | CDC42BPA | Q5VT25 | 1/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.48 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL12813301 | 0.84 | EGFR (0.71) | SYKEGFRGSK3BSCN9ASCN5A | |
| SCHEMBL3458766 | 0.80 | AIMP2 (0.58) | EGFRSCN9ASCN5APRKCD | |
| SCHEMBL3459161 | 0.78 | SRC (0.57) | SYKEGFR | |
| SCHEMBL3459641 | 0.77 | AIMP2 (0.50) | EGFRSCN9ASCN5AROCK1ROCK2 | |
| SCHEMBL3454379 | 0.76 | AIMP2 (0.56) | SYKEGFRSCN5APIK3CGPIK3CA | |
| SCHEMBL656019 | 0.76 | SYK (1.00) | SYKEGFR | |
| SCHEMBL3456182 | 0.75 | NOS3 (0.52) | SYKEGFRSCN9ASCN5AKCNH2 | |
| SCHEMBL3455914 | 0.75 | CCNA2 (0.47) | SYKEGFRSCN9ASCN5AKCNH2 | |
| SCHEMBL17150948 | 0.75 | SYK (0.52) | SYKEGFRGSK3BROCK1ROCK2 | |
| SCHEMBL14024536 | 0.73 | KDR (0.61) | SYKEGFRGSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2154967-A1 | PYRIMIDINE DERIVATIVES | Hutchison Medipharma Enterprises Limited (BS) | 2010-02-24 | — | — | EP | disclosed |
| WO-2008128231-A1 | PYRIMIDINE DERIVATIVES | HUTCHISON MEDIPHARMA ENTERPRISES LIMITED (BS) | 2008-10-23 | — | — | WO | disclosed |