Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 5/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | IDO1 | P14902 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | CA1 | P00915 | 2/20 | 0.31 |
| ▸ | CA2 | P00918 | 2/20 | 0.31 |
| ▸ | CA7 | P43166 | 2/20 | 0.31 |
| ▸ | CA9 | Q16790 | 2/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.30 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.30 |
| ▸ | CA12 | O43570 | 1/20 | 0.30 |
| ▸ | CA3 | P07451 | 1/20 | 0.30 |
| ▸ | CA6 | P23280 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20921311 | 0.80 | ACHE (0.42) | ACHETDP1MAPTIDO1GAA | |
| SCHEMBL20906472 | 0.80 | ACHE (0.42) | ACHETDP1MAPTIDO1GAA | |
| SCHEMBL3884085 | 0.78 | ACHE (0.40) | ACHETDP1MAPTIDO1GAA | |
| SCHEMBL12283711 | 0.78 | ACHE (0.40) | ACHETDP1MAPTIDO1GAA | |
| SCHEMBL2728956 | 0.76 | ACHE (0.38) | ACHETDP1MAPTIDO1GAA | |
| SCHEMBL2728483 | 0.76 | ACHE (0.38) | ACHETDP1MAPTIDO1GAA | |
| SCHEMBL17548365 | 0.76 | CYP2A6 (0.38) | ALDH1A1CA1CA2CYP2A6TAAR1 | |
| SCHEMBL11092898 | 0.76 | ACHE (0.38) | ACHETDP1MAPTIDO1GAA | |
| SCHEMBL17447443 | 0.76 | CYP1A2 (0.39) | ACHETDP1MAPTIDO1GAA | |
| SCHEMBL778068 | 0.75 | CYP3A4 (0.41) | TDP1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106986804-A | The electrophilic reagent based on sulfonium cation, its preparation and use for the transfer of monohaloalkyl methyl group | 霍维奥恩联合有限公司 | 2017-07-28 | — | — | CN | disclosed |
| EP-2632896-B1 | ELECTROPHILIC REAGENTS FOR MONOHALOMETHYLATION,THEIR PREPARATION AND THEIR USES | HOVIONE INT LTD (CH) | 2017-03-15 | — | — | EP | disclosed |
| EP-2632896-B1 | ELECTROPHILIC REAGENTS FOR MONOHALOMETHYLATION,THEIR PREPARATION AND THEIR USES | HOVIONE INT LTD (CH) | 2017-03-15 | — | — | EP | disclosed |
| US-9359294-B2 | Electrophilic reagents for monohalomethylation, their preparation and their uses | HOVIONE INTER LIMITED (CH) | 2016-06-07 | — | — | US | disclosed |
| US-9359294-B2 | Electrophilic reagents for monohalomethylation, their preparation and their uses | HOVIONE INTER LIMITED (CH) | 2016-06-07 | — | — | US | disclosed |
| US-9359294-B2 | Electrophilic reagents for monohalomethylation, their preparation and their uses | HOVIONE INTER LIMITED (CH) | 2016-06-07 | — | — | US | disclosed |
| US-20160130223-A1 | Electrophilic Reagents for Monohalomethylation, Their Preparation and Their Uses | HOVIONE INTER LIMITED (CH) | 2016-05-12 | — | — | US | disclosed |
| US-20160130223-A1 | Electrophilic Reagents for Monohalomethylation, Their Preparation and Their Uses | HOVIONE INTER LIMITED (CH) | 2016-05-12 | — | — | US | disclosed |
| US-20160130223-A1 | Electrophilic Reagents for Monohalomethylation, Their Preparation and Their Uses | HOVIONE INTER LIMITED (CH) | 2016-05-12 | — | — | US | disclosed |
| US-9290446-B2 | Electrophilic reagents for monohalomethylation, their preparation and their uses | HOVIONE INTER LIMITED (CH) | 2016-03-22 | — | — | US | disclosed |
| US-9290446-B2 | Electrophilic reagents for monohalomethylation, their preparation and their uses | HOVIONE INTER LIMITED (CH) | 2016-03-22 | — | — | US | disclosed |
| US-9290446-B2 | Electrophilic reagents for monohalomethylation, their preparation and their uses | HOVIONE INTER LIMITED (CH) | 2016-03-22 | — | — | US | disclosed |
| US-20130274460-A1 | Electrophilic Reagents for Monohalomethylation, Their Preparation and Their Uses | HOVIONE INTER LIMITED (CH) | 2013-10-17 | — | — | US | disclosed |
| US-20130274460-A1 | Electrophilic Reagents for Monohalomethylation, Their Preparation and Their Uses | HOVIONE INTER LIMITED (CH) | 2013-10-17 | — | — | US | disclosed |
| US-20130274460-A1 | Electrophilic Reagents for Monohalomethylation, Their Preparation and Their Uses | HOVIONE INTER LIMITED (CH) | 2013-10-17 | — | — | US | disclosed |
| EP-2632896-A2 | ELECTROPHILIC REAGENTS FOR MONOHALOMETHYLATION,THEIR PREPARATION AND THEIR USES | Hovione Inter Limited (CH) | 2013-09-04 | — | — | EP | disclosed |
| CN-103249716-A | Sulfonium-ion-based electrophiles for the transfer of monohalomethyl groups, their preparation and use | HOVIONE INT LTD | 2013-08-14 | — | — | CN | disclosed |
| WO-2012056201-A2 | ELECTROPHILIC REAGENTS FOR MONOHALOMETHYLATION,THEIR PREPARATION AND THEIR USES | HOVIONE INTER LIMITED (CH) | 2012-05-03 | — | — | WO | disclosed |
| WO-2012056201-A2 | ELECTROPHILIC REAGENTS FOR MONOHALOMETHYLATION,THEIR PREPARATION AND THEIR USES | HOVIONE INTER LIMITED (CH) | 2012-05-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130274460-A1 | Electrophilic Reagents for Monohalomethylation, Their Preparation and Their Uses | RFC2, FH, H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16 | ACHE 4602/4885TDP1 3239/4885MAPT 4699/4885 |
| US-20160130223-A1 | Electrophilic Reagents for Monohalomethylation, Their Preparation and Their Uses | CBR3, CBR1, H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16 | ACHE 3713/4885TDP1 1393/4885MAPT 4501/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.